Department of Medicine Biochemistry, Aydin Adnan Menderes University Institute of Health Sciences, Aydin, 09100, Turkey.
Department of Biochemistry, Samsun Training & Research Hospital, Samsun, 55090, Turkey.
Biomark Med. 2022 May;16(7):559-568. doi: 10.2217/bmm-2021-0688. Epub 2022 Mar 28.
Our study was designed on the hypothesis that homocysteine levels are a prognostic parameter that can predict the severity of COVID-19 disease. 117 COVID-19 patients and 34 non COVID-19 individuals were included in the study. Receiver operating characteristic (ROC) analysis was performed for homocysteine, D-dimer and monocyte/lymphocyte ratio (MLR) levels. According to the ROC analysis, in COVID-19 patients group, Area under curve (AUC) values were 0.835 for homocysteine, 0.859 for D-dimer and 0.882 for MLR. According to the ROC analysis, in which homocysteine, MLR and D-dimer parameters were evaluated together, AUC values were 0.951 in the mild disease group, 1000 in severe disease group and 0.967 in COVID-19 patients group. It was concluded that homocysteine level is an important parameter in the follow-up of COVID-19 disease.
我们的研究基于这样一个假设，即同型半胱氨酸水平是一个可以预测 COVID-19 疾病严重程度的预后参数。研究纳入了 117 名 COVID-19 患者和 34 名非 COVID-19 个体。对同型半胱氨酸、D-二聚体和单核细胞/淋巴细胞比值（MLR）水平进行了受试者工作特征（ROC）分析。根据 ROC 分析，在 COVID-19 患者组中，同型半胱氨酸、D-二聚体和 MLR 的 AUC 值分别为 0.835、0.859 和 0.882。根据 ROC 分析，在同时评估同型半胱氨酸、MLR 和 D-二聚体参数的情况下，轻度疾病组的 AUC 值为 0.951，重度疾病组为 100，COVID-19 患者组为 0.967。结论是同型半胱氨酸水平是 COVID-19 疾病随访的一个重要参数。
