Ridgway R L, Oaks S C, LaBarre D D
Lab Anim Sci. 1986 Oct;36(5):481-5.
A wide variety of animals have been utilized in an attempt to provide the information necessary to bring scrub typhus to the point where it is no longer a threat to man. The laboratory mouse is usually the animal of choice for the study of this disease. The discovery that certain strains of inbred mice are genetically resistant to Rickettsia tsutsugamushi, the agent of scrub typhus, has opened new avenues in the study of the immune response to the disease. The cynomolgus monkey, Macaca fascicularis, appears to be the best animal model for the study of scrub typhus as it occurs in humans and should be useful in the development of an efficacious vaccine.
为了获取将恙虫病控制到不再对人类构成威胁所需的信息，人们使用了各种各样的动物。实验室小鼠通常是研究这种疾病的首选动物。某些近交系小鼠对恙虫病病原体恙虫立克次体具有遗传抗性这一发现，为该疾病免疫反应的研究开辟了新途径。食蟹猴（猕猴属）似乎是研究人类恙虫病的最佳动物模型，在开发有效疫苗方面应该会很有用。
