Department of Epidemiology and Biostatistics, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Indian J Med Res. 2021 Mar;154(3):446-454. doi: 10.4103/ijmr.IJMR_817_18.
BACKGROUND & OBJECTIVES: Endometriosis is one of the causes of female infertility, but the prevalence of endometriosis is not exactly known. We conducted a systematic review and meta-analysis to provide an estimate of the prevalence of endometriosis in women considering the stage of disease, diagnostic method, geographical distribution, clinical symptoms and sample size.
MEDLINE, Web of Science, Google Scholar, Scopus and Cumulative Index of Nursing and Allied Health were searched to identify peer-reviewed studies published from January 1990 to December 2018 reporting the prevalence of endometriosis. Relevant additional articles were identified from the lists of the retrieved articles. Studies with cross-sectional design were included in the meta-analysis.
The overall prevalence of endometriosis was 18 per cent [95% confidence interval (CI): 16-20] and the prevalence of endometriosis by stage ranged from two per cent (95% CI: 1-4) for stage 4 to 20 per cent (95% CI: 11-28) for stage 1. The prevalence levels of endometriosis in women with infertility, chronic pelvic pain and asymptomatic were 31 (95% CI: 15-48), 42 (95% CI: 25-58) and 23 per cent (95% CI: 19-26), respectively.
INTERPRETATION & CONCLUSIONS: The results of this study showed that the prevalence of endometriosis in developing countries was high. Future studies are needed to explore other factors affecting the prevalence of endometriosis worldwide, which may help develop future prevention programmes.
子宫内膜异位症是女性不孕的原因之一，但子宫内膜异位症的患病率并不明确。我们进行了系统评价和荟萃分析，以提供考虑疾病分期、诊断方法、地理位置、临床症状和样本量等因素的子宫内膜异位症患病率的估计值。
检索 MEDLINE、Web of Science、Google Scholar、Scopus 和 Cumulative Index of Nursing and Allied Health，以确定 1990 年 1 月至 2018 年 12 月发表的报告子宫内膜异位症患病率的同行评审研究。从检索到的文章列表中确定了相关的额外文章。纳入横断面设计的研究进行荟萃分析。
子宫内膜异位症的总体患病率为 18%[95%置信区间（CI）：16-20%]，按分期的患病率从第 4 期的 2%（95%CI：1-4%）到第 1 期的 20%（95%CI：11-28%）不等。不孕、慢性盆腔痛和无症状女性的子宫内膜异位症患病率分别为 31%（95%CI：15-48%）、42%（95%CI：25-58%）和 23%（95%CI：19-26%）。
本研究结果表明，发展中国家子宫内膜异位症的患病率较高。需要进一步研究探索影响全球子宫内膜异位症患病率的其他因素，这可能有助于制定未来的预防计划。
