Department of Occupational Health, Hanoi Medical University, Hanoi, Viet Nam.
National Institute of Public Health, Lao PDR, Viet Nam.
Asian Pac J Cancer Prev. 2022 Mar 1;23(3):861-865. doi: 10.31557/APJCP.2022.23.3.861.
To examine the association between dietary intake of Trans-Lycopene and β-Cryptoxanthin and stomach cancer in Vietnamese men.
A case-control study including 80 male incident stomach cancer cases and 146 male controls was performed in a general hospital in Viet Nam. A validated semi-quantitative food frequency (SQFFQ) and demographic lifestyle questionnaire were designed, and venous blood samples were collected to determine H. pylori status by IgG ELISA. Nutrient intake was converted using the data of SQFFQ and the Nutritive Composition Table of Vietnamese Foods, updated in 2019. The respective associations between Trans-Lycopene and β-Cryptoxanthin intake and stomach cancer were examined using unconditional logistic regression analysis with adjustments for possible cofactors.
Both Trans-Lycopene and β-Cryptoxanthin intake and stomach cancer showed a significantly inverse association, tertile-3 versus tertile-1, (OR = 0.15, 95%CI: 0.06-0.35, p trend = 0.00) and (OR = 0.34, 95%CI: 0.14-0.79, p trend = 0.02, respectively). For Trans-Lycopene intake stratifying by H. pylori status remained the benefit effect against stomach cancer among H. pylori-negative participants (OR = 0.15, 95%CI: 0.03-0.69, p trend = 0.02) and H. pylori-positive participants (OR = 0.13, 95%CI: 0.04-0.42, p trend = 0.00).
Both Trans-Lycopene and β-Cryptoxanthin intake showed a strong protective effect against stomach cancer. The findings suggest that these two types of fat-soluble micronutrients would be considered as an anti-cancer therapy for both primary and secondary prevention.
研究越南男性中反式番茄红素和β-隐黄质的饮食摄入量与胃癌之间的关联。
在越南的一家综合医院进行了一项病例对照研究，包括 80 例男性胃癌新发病例和 146 例男性对照。设计了一份经过验证的半定量食物频率（SQFFQ）和人口统计学生活方式问卷，并采集静脉血样，通过 IgG ELISA 检测 H. pylori 状态。营养素摄入量是通过 SQFFQ 和 2019 年更新的《越南食物营养成分表》的数据转换而来的。使用无条件逻辑回归分析，在调整了可能的混杂因素后，分别检验了反式番茄红素和 β-隐黄质摄入与胃癌之间的关联。
反式番茄红素和 β-隐黄质的摄入量与胃癌均呈显著负相关，第三组与第一组相比，（OR=0.15，95%CI：0.06-0.35，p 趋势=0.00）和（OR=0.34，95%CI：0.14-0.79，p 趋势=0.02）。对于按 H. pylori 状态分层的反式番茄红素摄入量，在 H. pylori 阴性参与者中（OR=0.15，95%CI：0.03-0.69，p 趋势=0.02）和 H. pylori 阳性参与者中（OR=0.13，95%CI：0.04-0.42，p 趋势=0.00），仍有对抗胃癌的获益作用。
反式番茄红素和 β-隐黄质的摄入量均与胃癌有很强的保护作用。这些两种类型的脂溶性微量营养素可被视为原发性和二级预防的抗癌疗法。
