全食物来源的钙摄入量与越南胃癌的关系：病例对照研究。

Calcium Intake Contributed by Whole Foods and Gastric Cancer in Viet Nam: A Case‑Control Study.

机构信息

School of Medicine, International University of Health and Welfare, Narita City, Japan.

Faculty of Public Health, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet Nam.

出版信息

Nutr Cancer. 2023;75(4):1243-1253. doi: 10.1080/01635581.2023.2187721. Epub 2023 Mar 17.

DOI:10.1080/01635581.2023.2187721

PMID:36927374

Abstract

BACKGROUND

Recent studies revealed the potential tumor-suppressive effects of calcium. We aimed to investigate the association between dietary calcium intake contributed by whole foods and gastric cancer.

METHODS

466 gastric cancer cases and 1531 controls were extracted from the completed case-control studies in hospitals in Hanoi from 2017 to 2019. A validated semi-quantitative food frequency questionnaire was used to obtain data via face-to-face interviews with the trained interviewer. Calcium intake was calculated based on the food frequency intake per year. Adjusted odds ratios (OR) and 95% confidence intervals (95% CI) were calculated.

RESULTS

The study participants consumed less than 50% of 700 mg/day compared to the recommended calcium intake. With increasing calcium intake, we found a reduction in gastric cancer in both genders, men and women (adjusted OR and 95%CI, 5 vs. 1 quintile: 0.50 (0.36, 0.70), 0.000; 0.62 (0.42, 0.92), 0.019; and 0.30 (0.16, 0.57), 0.000, respectively). The inverse association remained in the subgroups of never-smokers and those with positive infection.

CONCLUSION

We observed substantial benefits of calcium intake from whole foods against gastric cancer in the Vietnamese population with a low nutritious status.

摘要

背景

最近的研究揭示了钙的潜在肿瘤抑制作用。我们旨在研究全食物来源的膳食钙摄入量与胃癌之间的关联。

方法

从 2017 年至 2019 年在河内医院完成的病例对照研究中提取了 466 例胃癌病例和 1531 例对照。通过经过培训的访谈员进行面对面访谈，使用经过验证的半定量食物频率问卷来获取数据。根据每年的食物频率摄入量来计算钙的摄入量。计算了调整后的比值比（OR）和 95％置信区间（95％CI）。

结果

与推荐的钙摄入量相比，研究参与者的钙摄入量不足 700mg/天的 50％。随着钙摄入量的增加，我们发现男性和女性的胃癌均减少（调整后的 OR 和 95％CI，五分位数 5 与 1：0.50（0.36，0.70），0.000；0.62（0.42，0.92），0.019；和 0.30（0.16，0.57），0.000，分别）。在从未吸烟者和感染阳性者的亚组中，这种负相关仍然存在。