Abdel-Sattar Essam, Ali Dalia E
Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, El-Kasr El-Aini Street, Cairo, 11562 Egypt.
Department of Pharmacognosy, Faculty of Pharmacy, Pharos University in Alexandria, Alexandria, Egypt.
Rev Bras Farmacogn. 2022;32(2):188-200. doi: 10.1007/s43450-022-00245-x. Epub 2022 Mar 23.
Pregnanes and pregnane glycosides or their esters are well-studied secondary metabolites, many of them exhibit immunomodulator, anticancer, antidiabetic, antarthritic, antiulcer, anti-nociceptive, hypolipidemic, anti-inflammatory, and antibacterial properties. Pregnane glycosides are widely distributed in the families Apocyanaceae and Asclepiadaceae. Plant members of the genus R.Br., Apocynaceae, are among the most studied species because of uses in traditional medicine or as food. They are a rich source of pregnane glycosides, as russelioside B. However, the bioactivity profile of this pregnane glycoside has not been reviewed until now. The present review aims to summarize the most important pharmacological and therapeutic applications of russelioside B with specific emphasis on the mechanism of actions associated with its administration in preclinical models. Russelioside B has many pharmacological effects including antidiabetic, anti-obesity, anti-nociceptive, antiulcer, anti-inflammatory, anti-arthritis effects, and antibiofilm, and wound healing activities. Despite its outstanding pharmacotherapeutic potential, russelioside B has never been tested in clinical trials. This review indicates that russelioside B is a potentially promising bioactive candidate, but further deeper mechanistic studies and clinical trials are needed in the future to elucidate its interaction with receptors of specific genes.
The online version contains supplementary material available at 10.1007/s43450-022-00245-x.
孕甾烷及其糖苷或酯是经过充分研究的次生代谢产物，其中许多具有免疫调节、抗癌、抗糖尿病、抗关节炎、抗溃疡、抗伤害感受、降血脂、抗炎和抗菌特性。孕甾烷糖苷广泛分布于夹竹桃科和萝摩科。夹竹桃科R.Br.属的植物成员是研究最多的物种之一，因其在传统医学或作为食物中的用途。它们是孕甾烷糖苷的丰富来源，如拉塞利oside B。然而，这种孕甾烷糖苷的生物活性概况至今尚未得到综述。本综述旨在总结拉塞利oside B最重要的药理和治疗应用，特别强调其在临床前模型中的给药相关作用机制。拉塞利oside B具有多种药理作用，包括抗糖尿病、抗肥胖、抗伤害感受、抗溃疡、抗炎、抗关节炎作用以及抗生物膜和伤口愈合活性。尽管其具有出色的药物治疗潜力，但拉塞利oside B从未在临床试验中进行过测试。本综述表明，拉塞利oside B是一种潜在有前景的生物活性候选物，但未来需要进一步深入的机制研究和临床试验来阐明其与特定基因受体的相互作用。
在线版本包含可在10.1007/s43450-022-00245-x获取的补充材料。
