新冠病毒之谜：成人多系统炎症综合征（MIS-A）是否可预测？
Enigma of COVID-19: is "multisystem inflammatory syndrome in adults" (MIS-A) predictable?
机构信息
Department of Hematology, Istanbul Training and Research Hospital, University of Health Sciences, Org.Nafiz GURMAN Cad. Fatih, 34098, Istanbul, Turkey.
Department of Clinical Microbiology and Infectious Diseases, Istanbul Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
出版信息
BMC Infect Dis. 2022 Mar 28;22(1):300. doi: 10.1186/s12879-022-07303-8.
BACKGROUND
Severe inflammation and one or more extrapulmonary organ dysfunctions have been reported and this clinical picture is defined as "multisystem inflammatory syndrome in adults" (MIS-A) in severe coronavirus disease-2019 (COVID-19). We aimed to determine the effect of LDH/lymphocyte ratio (LLR) on the development of MIS-A.
METHODS
The data of 2333 patients were retrospectively analyzed.
RESULTS
MIS-A rate was found to be 9.9% and MIS-A related mortality was 35.3%. LRR level above 0.24 was found to predict MIS-A development with 70% sensitivity and 65.2% specificity. The risk of MIS-A development was found to be 3.64 times higher in those with LRR levels above 0.24 compared to those with 0.24 and below. In patients with MIS-A, LRR level above 0.32 predicts mortality with 78% sensitivity and 70% specificity.
CONCLUSIONS
Early detection of MIS-A with high sensitivity and specificity in a practical ratio is very important in terms new studies.
背景
据报道，严重的炎症和一个或多个肺外器官功能障碍已经出现，这种临床表现在严重的 2019 冠状病毒病（COVID-19）中被定义为“成人多系统炎症综合征”（MIS-A）。我们旨在确定乳酸脱氢酶/淋巴细胞比值（LLR）对 MIS-A 发展的影响。
方法
回顾性分析了 2333 例患者的数据。
结果
MIS-A 发生率为 9.9%，MIS-A 相关死亡率为 35.3%。发现 LRR 水平高于 0.24 可预测 MIS-A 发生，其敏感性为 70%，特异性为 65.2%。与 LRR 水平低于 0.24 的患者相比，LRR 水平高于 0.24 的患者发生 MIS-A 的风险高 3.64 倍。在 MIS-A 患者中，LRR 水平高于 0.32 预测死亡率，其敏感性为 78%，特异性为 70%。
结论
在新的研究中，用实用比值以高敏感性和特异性早期检测 MIS-A 非常重要。
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