Giorgi A, Parodi F, Piacenza G, Mantellini E, Salio M, Cremonte L G, Grosso E
Minerva Med. 1986 Nov 10;77(42-43):2007-10.
An in vitro analysis was conducted to investigate the hypothetical antibacterial and antimycotic activity of the common anesthetic gases (halothane, enflurane, isoflurane, methoxyflurane) in view of the clinical absence of bronchopulmonary pathology after inhalation narcosis despite the many risk factors involved. For this purpose scalar dilutions of the four gases were prepared on cultures of Klebsiella pneumoniae and Candida albicans and the antibacterial action of the gases was tested in vitro. Even with the weaker concentrations used, halothane and methoxyflurane totally inhibited both microorganisms. Enflurane had less effect on Klebsiella p. and almost none on Candida. Isoflurane, a new halogen ether anesthetic was found to have an excellent inhibitory effect. In conclusion it is hypothesised that the anesthetic gases considered might have an in vivo antibacterial activity considering the experimental results obtained in vitro.
鉴于吸入麻醉后尽管存在诸多风险因素，但临床上并未出现支气管肺部病变，因此进行了一项体外分析，以研究常见麻醉气体（氟烷、恩氟烷、异氟烷、甲氧氟烷）假定的抗菌和抗真菌活性。为此，在肺炎克雷伯菌和白色念珠菌培养物上制备了这四种气体的系列稀释液，并在体外测试了这些气体的抗菌作用。即使使用较弱的浓度，氟烷和甲氧氟烷也完全抑制了这两种微生物。恩氟烷对肺炎克雷伯菌的作用较小，对白色念珠菌几乎没有作用。发现新型卤代醚麻醉剂异氟烷具有出色的抑制作用。总之，考虑到体外获得的实验结果，推测所研究的麻醉气体可能具有体内抗菌活性。
