Departamento de Hematologia, Hemoterapia e Terapia Celular da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.
Departamento de Hematologia, Hemoterapia e Terapia Celular da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil; Laboratório de Investigação Médica na Patogênese e Terapia dirigida em Onco-imuno-hematologia (LIM-31), Hospital das Clinicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.
Transfus Apher Sci. 2022 Aug;61(4):103424. doi: 10.1016/j.transci.2022.103424. Epub 2022 Mar 15.
Immediate adverse reactions experienced during donation decrease return rates among whole-blood donors, but little is known about this effect among platelet apheresis donors. We investigated the impact of immediate adverse reactions on the return rates of volunteer apheresis platelet donors.
In a sample of 4108 consecutive platelet apheresis donors seen from August 2016 through June 2019, we evaluated whether immediate adverse reactions were associated with returning for a subsequent platelet apheresis donation within a 12-month period. We used propensity score matching to compare donors with and without adverse reactions.
An immediate adverse reaction occurred in 312 (7.6%) donors; 98.5% were mild, and 0.3% were severe. Of the original 4108 platelet apheresis donors, only 3211 (72.3%) returned for a subsequent donation within 12 months. Experiencing an immediate adverse reaction during the donation process significantly decreased the return rate for a subsequent donation [HR= 0.74 (0.63-0.87)], especially among female donors [HR= 0.70 (0.53-0.93)], donors aged < 30 years [HR= 0.71 (0.54-0.94)], with a high school educational level [0.63 (0.49-0.81)], donors donating for the first time [HR= 0.73 (0.59-0.90)], and repeat donors with a previous platelet apheresis donation more than 180 days prior [HR= 0.68 (0.50-0.93)].
Even mild adverse events reduce the return rates for a subsequent donation among platelet apheresis donors. Female donors, younger donors, and first-time donors are at higher risk of not returning after an immediate adverse reaction. Preventing the incidence of immediate adverse reactions during platelet apheresis donation may increase the rate of donor retention.
捐献过程中出现的即时不良反应会降低全血捐献者的回捐率，但我们对血小板单采捐献者的这种影响知之甚少。我们调查了即时不良反应对志愿单采血小板捐献者回捐率的影响。
在 2016 年 8 月至 2019 年 6 月期间观察的 4108 名连续血小板单采捐献者中，我们评估了即时不良反应是否与 12 个月内再次进行血小板单采捐献有关。我们使用倾向评分匹配来比较有和无不良反应的捐献者。
312（7.6%）名捐献者发生了即时不良反应；98.5%为轻度，0.3%为重度。在最初的 4108 名血小板单采捐献者中，只有 3211（72.3%）人在 12 个月内再次捐献。在捐献过程中发生即时不良反应显著降低了随后的捐献回捐率[HR=0.74（0.63-0.87）]，尤其是女性捐献者[HR=0.70（0.53-0.93）]、年龄<30 岁的捐献者[HR=0.71（0.54-0.94）]、高中及以下学历的捐献者[HR=0.63（0.49-0.81）]、首次捐献的捐献者[HR=0.73（0.59-0.90）]和上次血小板单采捐献距当前时间>180 天的重复捐献者[HR=0.68（0.50-0.93）]。
即使是轻微的不良反应也会降低血小板单采捐献者随后的捐献回捐率。女性捐献者、年轻捐献者和首次捐献者在发生即时不良反应后不回捐的风险更高。预防血小板单采捐献过程中即时不良反应的发生可能会提高捐献者保留率。
