Park Byullee, Park Sinyoung, Kim Jeesu, Kim Chulhong
Departments of Convergence IT Engineering, Mechanical Engineering, and Electrical Engineering and Graduate School of Artificial Intelligence, Pohang University of Science and Technology (POSTECH), Pohang, Gyeongbuk, Republic of Korea.
Department of Optics and Mechatronics Engineering, Department of Cogno-Mechatronics Engineering, College of Nanoscience & Nanotechnology, Pusan National University, Busan, Republic of Korea.
Adv Drug Deliv Rev. 2022 May;184:114235. doi: 10.1016/j.addr.2022.114235. Epub 2022 Mar 25.
Administrating pharmaceutic agents efficiently to achieve the therapeutic effect is the aim of all drug delivery techniques. Recent drug delivery systems aim to deliver high doses of drugs to disease sites accurately while maximizing therapeutic effects and minimizing potential side effects. Key approaches apply image guidance techniques for the quantification of drug biodistribution and pharmacokinetic parameters during drug delivery. This review highlights recent research on image-guided drug delivery systems based on photoacoustic imaging, which has been attracting attention for its non-invasiveness, non-ionizing radiation, and real-time imaging functions. Photoacoustic imaging based on the photothermal conversion efficiency of agents can be easily combined with various phototherapeutics, making them highly suitable for drug delivery therapy platforms. Here, we summarize and compare the characteristics of various types of photoacoustic imaging systems, focus on contrast-enhanced photoacoustic imaging and controlled release of therapeutics in drug delivery systems for synergistic therapies.
高效给药以实现治疗效果是所有药物递送技术的目标。近期的药物递送系统旨在将高剂量药物准确地递送至疾病部位，同时最大化治疗效果并最小化潜在副作用。关键方法是应用图像引导技术来量化药物递送过程中的药物生物分布和药代动力学参数。本综述重点介绍了基于光声成像的图像引导药物递送系统的最新研究，该技术因其非侵入性、非电离辐射和实时成像功能而备受关注。基于试剂光热转换效率的光声成像可以很容易地与各种光疗法相结合，使其非常适合药物递送治疗平台。在此，我们总结并比较了各类光声成像系统的特点，重点关注药物递送系统中用于协同治疗的对比增强光声成像和治疗剂的控释。
