乳糜泻与 COVID-19 易感性和 COVID-19 重症风险：一项孟德尔随机化研究。
Celiac Disease and the Susceptibility of COVID-19 and the Risk of Severe COVID-19: A Mendelian Randomization Study.
机构信息
Department of Pathology, College of Basic Medical Sciences, Jilin University, Changchun, Jilin, China.
Experimental Center of Pathogenobiology, Immunology, Cytobiology and Genetics, College of Basic Medical Sciences, Jilin University, Changchun, Jilin, China.
出版信息
Clin Transl Gastroenterol. 2022 May 1;13(5):e00480. doi: 10.14309/ctg.0000000000000480.
INTRODUCTION
Previous observational studies have found that the susceptibility of coronavirus disease 2019 (COVID-19) and the risk of severe COVID-19 are not increased in patients with celiac disease (CeD). However, the findings of observational studies are prone to bias due to reverse causation and confounding factors, especially in the case of a newly emerged disease. In this study, we aimed to further clarify the underlying relationship by both observational and Mendelian randomization (MR) analysis.
METHODS
This observational study was conducted in the UK Biobank cohort. Univariate and multivariate logistic regression analyses were performed to identify the risk factors of COVID-19 susceptibility and severe COVID-19. To understand the causality between CeD and COVID-19 susceptibility and severe COVID-19, we performed a 2-sample MR analysis.
RESULTS
Our observational study showed that patients with CeD had a lower susceptibility of COVID-19 (odds ratio [OR] = 0.699, P = 0.006) while CeD was not significantly associated with severe COVID-19 (P > 0.05). The findings from our MR study further demonstrated that both the susceptibility to COVID-19 (OR = 0.963, P = 0.006) and severe COVID-19 (OR = 0.919, P = 0.049) were lower in patients with CeD, although the former seemed to be specific to the UK Biobank cohort.
DISCUSSION
Our results suggested that it may be unnecessary to take extra COVID-19 precaution in patients with CeD.
简介
先前的观察性研究发现，乳糜泻（CeD）患者感染 2019 年冠状病毒病（COVID-19）的易感性和 COVID-19 重症风险并未增加。然而，由于反向因果关系和混杂因素的影响，观察性研究的结果容易出现偏差，尤其是在新出现的疾病的情况下。在这项研究中，我们旨在通过观察性和孟德尔随机化（MR）分析进一步阐明潜在的关系。
方法
本观察性研究在英国生物库队列中进行。采用单变量和多变量逻辑回归分析来确定 COVID-19 易感性和 COVID-19 重症的危险因素。为了了解 CeD 与 COVID-19 易感性和 COVID-19 重症之间的因果关系，我们进行了两样本 MR 分析。
结果
我们的观察性研究表明，CeD 患者 COVID-19 的易感性较低（优势比[OR] = 0.699，P = 0.006），而 CeD 与 COVID-19 重症之间无显著相关性（P > 0.05）。MR 研究的结果进一步表明，CeD 患者 COVID-19 的易感性（OR = 0.963，P = 0.006）和 COVID-19 重症的风险（OR = 0.919，P = 0.049）均较低，尽管前者似乎仅限于英国生物库队列。
讨论
我们的结果表明，CeD 患者可能无需采取额外的 COVID-19 预防措施。
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