Hypertension Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
Heart Failure Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
Eur J Clin Nutr. 2022 Oct;76(10):1409-1414. doi: 10.1038/s41430-022-01118-1. Epub 2022 Mar 28.
The association between egg consumption and cardiovascular events remains controversial. This study aims to evaluate this association in cardiovascular events including myocardial infarction (MI), ischemic coronary heart disease (ICHD), stroke, cardiovascular disease (CVD), and CVD mortality in an Iranian population.
This prospective cohort study included 6504 adults (age ≥ 35 years) with no history of CVD event at baseline. The frequency of egg consumption was assessed using a validated food frequency questionnaire. Participants were followed for 12 years and incidence of new CVD cases were determined through active examinations and linkages to multiple registries. Cox frailty models were conducted to calculate adjusted hazard ratios (HR)s for cardiovascular events associated with egg consumption.
Over a median follow-up of 12 years, fully adjusted model [adjusted for age, sex, education, residency, smoking, daily physical activity, family history of CVD, metabolic syndrome, aspirin, body mass index and Global Dietary Index] revealed a null association between egg and cardiovascular events. Compared with non-consumers (<1 time/week), higher egg consumption (≥3 time/week) was not associated with incident MI (HR = 1.44, 95% CI: 0.86, 2.41; P = 0.48), ICHD (HR = 1.26, 95% CI: 0.80, 1.99; P = 0.41), stroke (HR = 0.79, 95% CI: 0.46, 1.38; P = 0.71) and CVD (HR = 1.05, 95% CI: 0.79, 1.40; P = 0.93).
These findings suggest that higher egg consumption is not associated with increased risk of MI, ICHD, stroke, and CVD among Iranians. Larger studies with longer duration of follow-up are warranted to explore these associations in populations with higher egg consumption.
鸡蛋摄入与心血管事件之间的关联仍存在争议。本研究旨在评估伊朗人群中心血管事件（包括心肌梗死（MI）、缺血性冠心病（ICHD）、中风、心血管疾病（CVD）和 CVD 死亡率）中这种关联。
这项前瞻性队列研究纳入了 6504 名基线时无 CVD 病史的成年人（年龄≥35 岁）。使用经过验证的食物频率问卷评估鸡蛋摄入的频率。通过主动检查和与多个登记处的联系对参与者进行了 12 年的随访，并确定新发生的 CVD 病例。使用 Cox 脆弱性模型计算与鸡蛋摄入相关的心血管事件的调整后危险比（HR）。
在中位随访 12 年期间，完全调整后的模型（按年龄、性别、教育程度、居住地、吸烟、日常体力活动、CVD 家族史、代谢综合征、阿司匹林、体重指数和全球饮食指数调整）显示鸡蛋与心血管事件之间呈零关联。与非食用者（<每周 1 次）相比，更高的鸡蛋摄入量（≥每周 3 次）与新发 MI（HR=1.44，95%CI：0.86，2.41；P=0.48）、ICHD（HR=1.26，95%CI：0.80，1.99；P=0.41）、中风（HR=0.79，95%CI：0.46，1.38；P=0.71）和 CVD（HR=1.05，95%CI：0.79，1.40；P=0.93）无关。
这些发现表明，在伊朗人群中，较高的鸡蛋摄入量与 MI、ICHD、中风和 CVD 的风险增加无关。需要进行更大规模、随访时间更长的研究来探索这些在鸡蛋摄入量较高的人群中的关联。
