Loulergue J, Besnier J M, Cibois D, Rosset P, Audurier A
Pathol Biol (Paris). 1986 May;34(5):521-4.
Since 1982 we have administered cloxacillin intraoperatively during total hip replacement. 1 g cloxacillin is injected intravenously at induction of anesthesia, followed by 1g every hour until the end of the procedure or a total of 6 g. In our study, cloxacillin concentrations were determined in the fluid collected from the deep suction catheter inserted at the end of the surgical procedure. Fluid samples were collected 2 h, 4 h, 6 h, 8 h and 24 hours after the last injection of cloxacillin. Serum samples were taken 2 h, 6 h and 24 hours after the last injection. Cloxacillin was assayed using an agar-diffusion microbiologic method. 18 patients were studied. Each had received 3 to 5 g cloxacillin over 3 to 5 hours. Mean suction catheter fluid concentrations were to 69.7 micrograms/ml, 37.6 micrograms/ml, 24.2 micrograms/ml, 15.5 micrograms/ml, and 6.8 micrograms/ml respectively in the samples collected 2 h, 4 h, 6 h, 8 h and 24 hours after the last injection of cloxacillin. Mean serum concentrations were 34.1 micrograms/ml, 4.2 micrograms/ml, and 0 microgram/ml respectively 2 h, 6 h and 24 hours after the last injection. Our results indicate that cloxacillin concentrations within the hip joint are probably effective against staphylococci for 8 to 12 hours.
自1982年以来，我们在全髋关节置换术中术中使用氯唑西林。在麻醉诱导时静脉注射1g氯唑西林，随后每小时注射1g，直至手术结束或总量达6g。在我们的研究中，对手术结束时插入的深部吸引导管收集的液体中的氯唑西林浓度进行了测定。在最后一次注射氯唑西林后2小时、4小时、6小时、8小时和24小时收集液体样本。在最后一次注射后2小时、6小时和24小时采集血清样本。使用琼脂扩散微生物学方法测定氯唑西林。对18名患者进行了研究。每位患者在3至5小时内接受了3至5g氯唑西林。在最后一次注射氯唑西林后2小时、4小时、6小时、8小时和24小时收集的样本中，平均吸引导管液体浓度分别为69.7微克/毫升、37.6微克/毫升、24.2微克/毫升、15.5微克/毫升和6.8微克/毫升。最后一次注射后2小时、6小时和24小时的平均血清浓度分别为34.1微克/毫升、4.2微克/毫升和0微克/毫升。我们的结果表明，髋关节内的氯唑西林浓度可能在8至12小时内对葡萄球菌有效。
