Department of Reproductive Medicine, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.
New England Fertility Institute, Stamford, CT, USA.
Cell Transplant. 2022 Jan-Dec;31:9636897221083252. doi: 10.1177/09636897221083252.
Physical and mental health and hormonal imbalance are associated with the problems related to infertility and reproductive disorders. The rate of infertility has increased globally over the years, due to various reasons. Given the psychosocial implications of infertility and its effects on the life of the affected people, there has been an increased focus on its treatment over the last several years. Assisted reproductive technology can only solve about 50% of the cases. Moreover, it contains significant risks and does not solve the fundamental problem of infertility. As pluripotent stem cells have the potential to differentiate into almost any type of cell, they have been widely regarded as a promising option in the development of stem cell-based fertility treatments, which could even correct genetic diseases in offspring. These advancements in reproductive biotechnology present both challenges and possibilities for solving infertility problems caused by various unexplainable factors. This review briefly presents the different types of infertility disorders and the potential applications of stem cells in the treatment of these reproductive diseases.
身心健康和激素失衡与不孕和生殖障碍相关问题有关。由于各种原因，近年来全球不孕率不断上升。鉴于不孕的心理社会影响及其对受影响者生活的影响，过去几年人们越来越关注其治疗方法。辅助生殖技术只能解决大约 50%的病例。此外，它还存在重大风险，并且不能解决不孕的根本问题。由于多能干细胞具有分化为几乎任何类型细胞的潜力，因此它们被广泛认为是基于干细胞的生育治疗发展的有前途的选择，甚至可以纠正后代的遗传疾病。生殖生物技术的这些进步为解决由各种不明原因因素引起的不孕问题带来了挑战和可能性。本文简要介绍了不同类型的不孕障碍和干细胞在治疗这些生殖疾病中的潜在应用。
