Department of Pediatrics/Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), West China Second University Hospital, Chengdu, Sichuan 610041, P.R. China.
Mol Med Rep. 2022 May;25(5). doi: 10.3892/mmr.2022.12699. Epub 2022 Mar 29.
Behavioral assessment is the dominant approach for evaluating whether animal models of brain diseases can successfully mimic the clinical characteristics of diseases. At present, most research regarding brain diseases involves the use of rodent models. While studies have reported numerous methods of behavioral assessments in rodent models of brain diseases, each with different principles, procedures, and assessment criteria, only few reviews have focused on characterizing and differentiating these methods based on applications for which they are most appropriate. Therefore, in the present review, the representative behavioral tests in rodent models of brain diseases were compared and differentiated, aiming to provide convenience for researchers in selecting the optimal methods for their studies.
行为评估是评估脑疾病动物模型能否成功模拟疾病临床特征的主要方法。目前，大多数脑疾病相关研究都涉及使用啮齿动物模型。虽然已有研究报道了脑疾病啮齿动物模型中多种行为评估方法，这些方法具有不同的原理、程序和评估标准，但仅有少数综述侧重于根据这些方法最适用的应用来对其进行特征描述和区分。因此，在本综述中，比较和区分了脑疾病啮齿动物模型中的代表性行为测试，旨在为研究人员选择最适合其研究的最佳方法提供便利。
