Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Division of Nephrology, Nanfang Hospital, Southern Medical University; National Clinical Research Center for Kidney Disease; State Key Laboratory of Organ Failure Research; Guangdong Provincial Institute of Nephrology; Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou, China.
Am J Clin Nutr. 2022 Jul 6;116(1):263-273. doi: 10.1093/ajcn/nqac073.
Ultraprocessing makes food products more convenient, appealing, and profitable. Recent studies show that high ultraprocessed food (UPF) intake is associated with cardiometabolic diseases.
The aim of this study is to investigate the association between UPF consumption and risks of kidney function decline in the general population.
In a prospective, general population-based Lifelines cohort from Northern Netherlands, 78,346 participants free of chronic kidney disease (CKD) at baseline responded to a 110-item FFQ. We used a multivariable regression analysis to study the associations of the proportion (in grams/day) of UPFs in the total diet with a composite kidney outcome [incident CKD or a ≥30% estimated glomerular filtration rate (eGFR) decline relative to baseline] and annual change in eGFR.
On average, 37.7% of total food intake came from UPFs. After 3.6 ± 0.9 years of follow-up, 2470 participants (3.2%) reached the composite kidney outcome. Participants in the highest quartile of UPF consumption were associated with a higher risk of the composite kidney outcome (OR, 1.27; 95% CI, 1.09-1.47; P = 0.003) compared with those in the lowest quartile, regardless of their macro- or micronutrient intake or diet quality. Participants in the highest quartile had a more rapid eGFR decline (β, -0.17; 95% CI, -0.23 to -0.11; P < 0.001) compared with those in the lowest quartile. Associations were generally consistent across different subgroups.
Higher UPF consumption was associated with a higher risk of a composite kidney outcome (incident CKD or ≥30% eGFR decline) and a more rapid eGFR decline in the general population, independent of confounders and other dietary indices.
超加工使食品更方便、更具吸引力、更有利可图。最近的研究表明，高超加工食品（UPF）的摄入量与心血管代谢疾病有关。
本研究旨在调查一般人群中超加工食品（UPF）的摄入量与肾功能下降风险之间的关系。
在荷兰北部的一个前瞻性、基于一般人群的莱夫兰斯队列研究中，78346 名基线时无慢性肾脏病（CKD）的参与者对 110 项食物频率问卷进行了回应。我们使用多变量回归分析来研究总饮食中 UPF 比例（以克/天计）与复合肾脏结局[新发 CKD 或与基线相比 eGFR 下降≥30%]和 eGFR 年变化的关系。
平均而言，总食物摄入量的 37.7%来自 UPF。经过 3.6±0.9 年的随访，2470 名参与者（3.2%）达到了复合肾脏结局。与最低四分位组相比，最高四分位组 UPF 摄入量与复合肾脏结局的风险较高相关（OR，1.27；95%CI，1.09-1.47；P=0.003），无论他们的宏量或微量营养素摄入量或饮食质量如何。与最低四分位组相比，最高四分位组的 eGFR 下降速度更快（β，-0.17；95%CI，-0.23 至-0.11；P<0.001）。各亚组之间的相关性基本一致。
在一般人群中，较高的 UPF 摄入量与复合肾脏结局（新发 CKD 或 eGFR 下降≥30%）的风险增加以及 eGFR 下降速度加快有关，这与混杂因素和其他饮食指数无关。
