Institute for Glycomics, Griffith University, Parklands Dr. Southport, QLD 4222, Australia.
Signal Processing Laboratory, School of Engineering and Built Environment, Griffith University, Brisbane, QLD 4111, Australia.
Brief Bioinform. 2022 May 13;23(3). doi: 10.1093/bib/bbac112.
Characterizing RNA structures and functions have mostly been focused on 2D, secondary and 3D, tertiary structures. Recent advances in experimental and computational techniques for probing or predicting RNA solvent accessibility make this 1D representation of tertiary structures an increasingly attractive feature to explore. Here, we provide a survey of these recent developments, which indicate the emergence of solvent accessibility as a simple 1D property, adding to secondary and tertiary structures for investigating complex structure-function relations of RNAs.
RNA 结构和功能的研究主要集中在二维、二级和三维、三级结构上。最近在探测或预测 RNA 溶剂可及性的实验和计算技术方面的进展，使得这种三级结构的一维表示形式成为一种越来越有吸引力的探索特征。在这里，我们提供了对这些最新进展的调查，这些进展表明，溶剂可及性作为一种简单的一维性质的出现，增加了二级和三级结构，用于研究 RNA 的复杂结构-功能关系。
