Research Institute of Human Morphology, Moscow, Russia.
A. N. Severtsov Institute of Ecology and Evolution, Russian Academy of Science, Moscow, Russia.
Bull Exp Biol Med. 2022 Mar;172(5):561-565. doi: 10.1007/s10517-022-05433-2. Epub 2022 Mar 29.
The dynamics of proliferative activity of the L-929 cell culture of mouse fibroblast-like cells in the phase of logarithmic growth was compared with some heliogeophysical parameters (Ap and ULF indexes of geomagnetic activity, vertical component of the interplanetary magnetic field, and intensity of fluctuations of secondary cosmic radiation estimated by the neutron monitoring near the Earth's surface). Among the considered heliogeophysical parameters, only the magnitude of fluctuations of minute-to-minute changes in the neutron monitor indicator reliably and negatively correlates with the rate of cell culture reproduction. Considering that the amplitude of secondary cosmic fluctuations is about 5%, which is 0.1% of the total ray flux, and proliferative activity varies in the range of 30-50%, the probability of a direct biotrophic effect of this physical factor is extremely low. It seems likely that proliferative activity of L-929 cell culture is directly affected by another environmental factor, the marker of which is the intensity of neutron counting rate fluctuations.
比较了对数生长期小鼠成纤维样细胞 L-929 细胞培养物增殖活性的动力学与某些地磁活动参数（Ap 和极低频指数、行星际磁场的垂直分量以及近地表利用中子监测估计的次级宇宙辐射的波动强度）。在所考虑的地磁活动参数中，只有中子监测器指标分钟级波动幅度可靠地与细胞培养物繁殖率呈负相关。考虑到次级宇宙波动的幅度约为 5%，这是总射线通量的 0.1%，而增殖活性变化范围为 30-50%，因此该物理因素的直接生物营养作用的可能性极低。似乎 L-929 细胞培养物的增殖活性受到另一个环境因素的直接影响，其标志物是中子计数率波动的强度。
