Halberg Franz, Cornélissen Germaine, Wang Zhengrong, Wan Chaomin, Ulmer Waldemar, Katinas George, Singh Ranjana, Singh R K, Singh Rajesh Kumar, Gupta B D, Singh R B, Kumar Adarsh, Kanabrocki Eugene, Sothern Robert B, Rao Gundu, Bhatt Madan L B, Srivastava Madhu, Rai Gulshan, Singh Subhash, Pati Atanu Kumar, Nath Panchanan, Halberg Francine, Halberg Julia, Schwartzkopff Othild, Bakken Earl
University of Minnesota, Minneapolis, MN, USA.
J Exp Ther Oncol. 2003 Sep-Oct;3(5):223-60. doi: 10.1111/j.1533-869x.2003.01097.x.
We suggest a putative benefit from timing nutriceuticals (substances that are both nutrients and pharmaceuticals) such as antioxidants for preventive or curative health care, based on the proven merits of timing nutrients, drugs, and other treatments, as documented, i.a., in India. The necessity of timing melatonin, a major antioxidant, is noted. A protocol to extend the scope of chronoradiotherapy awaits testing. Imaging in time by mapping rhythms and broader time structures, chronomes, for earliest diagnoses, for example detection of vascular disease risk, is recommended. The study of rhythms and broader chronomes leads to a dynamic functional genomics, guided by imaging in time of free radicals and antioxidants, amongst many other variables.
基于营养物质、药物及其他治疗手段适时应用已被证实的益处(如在印度所记录的那样),我们认为适时摄入营养保健品(兼具营养成分和药物功效的物质),如抗氧化剂,对预防或治疗性医疗保健可能有益。文中指出了适时摄入褪黑素(一种主要的抗氧化剂)的必要性。一项扩展时辰放疗范围的方案有待测试。建议通过绘制节律和更广泛的时间结构(生物钟)进行适时成像,以实现最早诊断,例如检测血管疾病风险。对节律和更广泛生物钟的研究可导向动态功能基因组学,其由自由基和抗氧化剂的适时成像以及许多其他变量引导。