ω-3和ω-6多不饱和脂肪酸（PUFA）以及维生素D缺乏作为肥胖中代谢综合征风险决定因素的作用：基于工作场所的病例对照观察性研究。

Role of omega 3 and omega 6 poly unsaturated fatty acids (PUFA) and vitamin D deficiency as risk determinants of metabolic syndrome in obesity: Worksite based case-control observational study.

作者信息

Negi Prakash Chand, Sharma Chander Kant, Nihjawan Rahul, Sharma Rajesh, Asotra Sanjeev

机构信息

Department of Cardiology, Indira Gandhi Medical College, Shimla, HP, India.

Multi Disciplinary Research Unit, Indira Gandhi Medical College, Shimla, HP, India.

出版信息

Diabetes Metab Syndr. 2022 Apr;16(4):102467. doi: 10.1016/j.dsx.2022.102467. Epub 2022 Mar 18.

DOI:10.1016/j.dsx.2022.102467

PMID:35349963

Abstract

BACKGROUND AND AIMS

Risk factors for metabolic syndrome among obese population are not clear. The role of Eicosapentaenoic acid (EPA), Arachidonic acid (AA) Poly Unsaturated Fatty Acids (PUFA), their ratio and vitamin D deficiency as risk factors of metabolic syndrome (MS) was explored in obese worksite workers.

METHODS

The 145 obese worksite workers were enrolled and MS was diagnosed using adult treatment panel III criteria. The levels of EPA, AA PUFA were estimated using liquid chromatography-Mass Spectrometer and vitamin D levels with ELISA method. The association of MS with the tertiles of EPA, AA PUFAs, their ratio and vitamin D was estimated by calculating odds ratio and 95% C.I., taking lowest tertiles as the reference group using logistic regression model adjusted for age and gender.

RESULTS

105 out of 145 obese worksite workers; 72.4%, 95% C.I. (64.5%, 79.5%) had metabolic syndrome. The odd of MS was significantly lower in the group having highest tertiles of EPA 0.24 (0.09, 0.71) and was higher 2.0 (1.02, 3.89) in subjects with highest tertiles of AA: EPA ratio. The AA PUFA and vitamin D levels had no significant association with MS.

CONCLUSION

The low levels of omega 3 PUFA (EPA) and elevated ratio of AA: EPA PUFA was significantly associated with MS in obese works site workers.

摘要

背景与目的

肥胖人群中代谢综合征的危险因素尚不清楚。本研究在肥胖的在职员工中探讨了二十碳五烯酸（EPA）、花生四烯酸（AA）、多不饱和脂肪酸（PUFA）及其比例以及维生素D缺乏作为代谢综合征（MS）危险因素的作用。

方法

招募了145名肥胖的在职员工，并采用成人治疗小组III标准诊断代谢综合征。使用液相色谱 - 质谱仪估算EPA、AA、PUFA的水平，采用酶联免疫吸附测定法测定维生素D水平。通过计算比值比和95%置信区间，以最低三分位数作为参照组，采用经年龄和性别调整的逻辑回归模型，评估代谢综合征与EPA、AA、PUFA三分位数及其比例和维生素D的相关性。

结果

145名肥胖在职员工中有105名（72.4%，95%置信区间为64.5%，79.5%）患有代谢综合征。EPA三分位数最高的组中患代谢综合征的几率显著降低，为0.24（0.09，0.71），而AA与EPA比例三分位数最高的受试者中患代谢综合征的几率较高，为2.0（1.02，3.89）。AA、PUFA水平和维生素D水平与代谢综合征无显著相关性。