Johansson K E, Tibbling L
Scand J Gastroenterol. 1986 Sep;21(7):779-88. doi: 10.3109/00365528609011117.
The study comprises 31 patients with gastro-oesophageal reflux disease who received 8 weeks' treatment with ranitidine. Sixteen of the patients received in addition maintenance treatment with ranitidine (150 mg twice daily) for another 6 months, and fundoplication was performed on 15 patients. There was a significant improvement in endoscopic and histologic findings, a decrease in gastric acid secretion, and a reduction of symptoms during short-term treatment with ranitidine. No further improvement was seen in any of the factors after half a year of ranitidine. After surgery the total reflux time during 24 h decreased to practically zero, all patients had normal endoscopic findings and negative acid perfusion tests, and reflux symptoms had disappeared completely. Anti-reflux surgery was superior to treatment with ranitidine. Reflux oesophagitis is therefore not improved any further by a half year's treatment with ranitidine beyond what is achieved with short-term therapy.
该研究包括31例胃食管反流病患者，他们接受了8周的雷尼替丁治疗。其中16例患者还接受了雷尼替丁（每日两次，每次150毫克）的维持治疗，持续6个月，另有15例患者接受了胃底折叠术。雷尼替丁短期治疗期间，内镜和组织学检查结果有显著改善，胃酸分泌减少，症状减轻。雷尼替丁治疗半年后，任何因素均未进一步改善。手术后，24小时总反流时间几乎降至零，所有患者内镜检查结果正常，酸灌注试验阴性，反流症状完全消失。抗反流手术优于雷尼替丁治疗。因此，雷尼替丁治疗半年对反流性食管炎的改善并不比短期治疗更好。
