Li Zhiang, Zhang Lei, Li Lijun, Du Zhang
Department of Anorectal Surgery, Dongyang People's Hospital, 60 West Wuning Road, Zhejiang, 322100, China.
Biol Trace Elem Res. 2023 Feb;201(2):683-688. doi: 10.1007/s12011-022-03212-8. Epub 2022 Mar 30.
Celiac disease is a multisystem immune based disorder, caused by an immune-mediated reaction to ingested gluten with increasing prevalence in the USA. Celiac disease can cause a wide variety of symptoms, including gastrointestinal symptoms (diarrhea, abdominal distention, or abdominal pain), which may affect absorption of many nutritional components. All patients with celiac disease should remain on a strict and lifelong gluten-free diet, which are often low in certain trace elements such as zinc. On the other hand, zinc and copper as the essential trace elements have been hypothesized to help maintain optimum function of the immune system. Then, this study aims to examine the association between celiac disease seropositivity and serum zinc and copper levels. A nationally representative sample from National Health and Nutrition Examination Survey (2011-2014) was analyzed. Celiac disease seropositivity was determined using the tissue transglutaminase IgA antibody test (IgA-TTG). Multivariable linear regression models were performed with celiac disease seropositivity as a predictor and serum zinc and copper levels as outcome. The present study included 4732 participants (1398 children aged 6-19 years and 3334 adults aged ≥ 20 years). The weighted prevalence of celiac disease seropositivity was higher (11.6/1000) among children aged 6-19 years compared to that (6.3/1000) among adults aged ≥ 20 years. In the stratified analysis by age, the multivariable linear regression analysis revealed that among children aged 6-19 years, celiac disease seropositivity was associated with 5.32 (95% CI, - 9.71 to - 0.92) μg/dL lower serum zinc level, but not associated with serum copper level. However, the association between celiac disease seropositivity and serum zinc level was not statistically significant among adults aged 20 years or older. Future prospective studies are warranted to confirm these findings.
乳糜泻是一种基于多系统免疫的疾病，由对摄入麸质的免疫介导反应引起，在美国的患病率呈上升趋势。乳糜泻可导致多种症状，包括胃肠道症状（腹泻、腹胀或腹痛），这可能会影响许多营养成分的吸收。所有乳糜泻患者都应终生严格遵循无麸质饮食，这种饮食中的某些微量元素（如锌）含量通常较低。另一方面，锌和铜作为必需微量元素，据推测有助于维持免疫系统的最佳功能。因此，本研究旨在探讨乳糜泻血清阳性与血清锌和铜水平之间的关联。对来自国家健康与营养检查调查（2011 - 2014年）的具有全国代表性的样本进行了分析。使用组织转谷氨酰胺酶IgA抗体检测（IgA - TTG）来确定乳糜泻血清阳性。以乳糜泻血清阳性为预测指标，血清锌和铜水平为结果进行多变量线性回归模型分析。本研究纳入了4732名参与者（1398名6 - 19岁儿童和3334名20岁及以上成年人）。6 - 19岁儿童中乳糜泻血清阳性的加权患病率（11.6/1000）高于20岁及以上成年人（6.3/1000）。在按年龄分层分析中，多变量线性回归分析显示，在6 - 19岁儿童中，乳糜泻血清阳性与血清锌水平降低5.32（95%CI， - 9.71至 - 0.92）μg/dL相关，但与血清铜水平无关。然而，在20岁及以上成年人中，乳糜泻血清阳性与血清锌水平之间的关联无统计学意义。未来有必要进行前瞻性研究以证实这些发现。
