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[关于慢性肾小球肾炎治疗效果的新结果。来自一项回顾性研究的细胞抑制剂-抗凝剂-聚集抑制剂、细胞抑制剂-抗凝剂-聚集抑制剂-泼尼松以及细胞抑制剂-泼尼松治疗的结果]

[New results concerning the effectiveness of therapy of chronic glomerulonephritis. Results of cytostatics-anticoagulants-aggregation inhibitors, cystostatics-anticoagulants-aggregation inhibitors-prednisone and cystostatics-prednisone therapy, derived from a retrospective study].

作者信息

Sinn W, Ratner M, Tomilina N, Klinkmann H, Nizze H

出版信息

Z Urol Nephrol. 1986 Aug;79(8):449-57.

PMID:3535293
Abstract

The indication and effectiveness of the immunosuppressive therapy of chronic glomerulonephritis is now as ever controversial. As a result of a retrospective therapy study in an at least one-year therapy with cytostatics, thrombocyte aggregation inhibitors and anticoagulants (CAA-therapy, n = 27), additional prednisone therapy (CAAP-therapy, n = 95) and cytostatic-prednisone therapy (CP-therapy, n = 33) we find favourable results for the CAA/CAAP-therapy in the nephrotic syndrome and glomerulonephritides with distinct clinical exacerbation also in sclerosations in histology. Clinically inactive nephritides with exclusive urinary findings and sclerosations cannot be influenced therapeutically.

摘要

慢性肾小球肾炎免疫抑制治疗的适应症和有效性一如既往地存在争议。通过一项回顾性治疗研究,该研究采用细胞抑制剂、血小板聚集抑制剂和抗凝剂进行至少一年的治疗(CAA治疗,n = 27)、额外的泼尼松治疗(CAAP治疗,n = 95)以及细胞抑制-泼尼松治疗(CP治疗,n = 33),我们发现CAA/CAAP治疗在肾病综合征和肾小球肾炎中取得了良好效果,在组织学的硬化病变中也有明显的临床病情加重。仅有尿液检查结果和硬化病变的临床非活动性肾炎无法通过治疗得到改善。

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