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[原发性肾小球肾炎的治疗。细胞抑制剂-泼尼松与细胞抑制剂-抗凝剂-聚集抑制剂联合治疗效果的比较研究]

[Therapy of primary glomerulonephritis. Comparative study on the effect of cytostatics-prednisone and cytostatics-anticoagulant-aggregation inhibitor combination].

作者信息

Schmitt E, Kröger E, Lakner V, Klinkmann H, Ratner M, Tomilina N

出版信息

Z Gesamte Inn Med. 1979 Sep 1;34(17):465-71.

PMID:539014
Abstract

The result of the treatment with chlorambucil, dipyridamol, heparin/warfarin and prednisone on 50 patients as well as with imuran and prednisone on 32 patients is compared. Basis for this is a detailed morphological and clinical subdivision. With the help of therapy results is tried to derive regions of indication: the therapy with cytostatics, anticoagulants and aggregation inhibitors is above all suitable for patients with a short duration of the disease and with sign of activity, also in renal insufficiency. On the other hand the therapy with cytostatics and prednisone is also successful in patients with longer duration of the disease and missing signs of activity.

摘要

比较了苯丁酸氮芥、双嘧达莫、肝素/华法林和泼尼松对50例患者的治疗结果,以及硫唑嘌呤和泼尼松对32例患者的治疗结果。其依据是详细的形态学和临床细分。借助治疗结果试图得出适应证范围:细胞毒性药物、抗凝剂和聚集抑制剂治疗尤其适用于病程短且有活动迹象的患者,肾功能不全患者也适用。另一方面,细胞毒性药物和泼尼松治疗对病程较长且无活动迹象的患者也有效。

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