大气污染物对急性心肌梗死患者循环炎症细胞及 microRNA 表达的影响。

Influence of air pollutants on circulating inflammatory cells and microRNA expression in acute myocardial infarction.

机构信息

Department of Cardiology, Instituto de Investigación Sanitaria Hospital Universitario de La Princesa (IISP), Universidad Autónoma de Madrid, c/Diego de León 62, 28006, Madrid, Spain.

Vascular Pathophysiology Area, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.

出版信息

Sci Rep. 2022 Mar 30;12(1):5350. doi: 10.1038/s41598-022-09383-7.

Air pollutants increase the risk and mortality of myocardial infarction (MI). The aim of this study was to assess the inflammatory changes in circulating immune cells and microRNAs in MIs related to short-term exposure to air pollutants. We studied 192 patients with acute coronary syndromes and 57 controls with stable angina. For each patient, air pollution exposure in the 24-h before admission, was collected. All patients underwent systematic circulating inflammatory cell analyses. According to PM exposure, 31 patients were selected for microRNA analyses. STEMI patients exposed to PM showed a reduction of CD4 regulatory T cells. Furthermore, in STEMI patients the exposure to PM was associated with an increase of miR-146a-5p and miR-423-3p. In STEMI and NSTEMI patients PM exposure was associated with an increase of miR-let-7f-5p. STEMI related to PM short-term exposure is associated with changes involving regulatory T cells, miR-146a-5p and miR-423-3p.

空气污染物增加心肌梗死（MI）的风险和死亡率。本研究旨在评估与短期暴露于空气污染物相关的循环免疫细胞和 microRNAs 的炎症变化。我们研究了 192 名急性冠状动脉综合征患者和 57 名稳定型心绞痛对照者。对于每位患者，在入院前 24 小时内收集了空气污染暴露情况。所有患者均进行了系统的循环炎症细胞分析。根据 PM 暴露情况，选择 31 名患者进行 microRNA 分析。暴露于 PM 的 STEMI 患者表现出 CD4 调节性 T 细胞减少。此外，在 STEMI 患者中，PM 暴露与 miR-146a-5p 和 miR-423-3p 的增加相关。在 STEMI 和 NSTEMI 患者中，PM 暴露与 miR-let-7f-5p 的增加相关。与 PM 短期暴露相关的 STEMI 与涉及调节性 T 细胞、miR-146a-5p 和 miR-423-3p 的变化相关。