Institute of Public Health, Ministry of Health, Ho Chi Minh City, Viet Nam.
Western Pac Surveill Response J. 2022 Jan 6;13(1):1-7. doi: 10.5365/wpsar.2022.13.1.887. eCollection 2022 Jan-Mar.
To investigate the cause of a botulism outbreak in several provinces in Viet Nam in 2020.
An initial investigation was conducted to confirm the outbreak and to form hypotheses about the potential causes, followed by a case-control assessment of the plausible causative food item. Collected food samples were tested to identify the pathogen, and mouse bioassays were performed. Control measures were introduced to stop the outbreak and to prevent similar events in the future.
Twelve people in six southern provinces of Viet Nam were identified as having symptoms of botulism, of whom 11 were in critical condition requiring breathing support. A history of foods eaten in the 4 days before illness onset indicated that all the cases had eaten a tinned vegetarian pâté, and a case-control assessment showed that this was significantly associated with the outbreak, with an odds ratio of 35.2 (95% confidence interval: 3.4-¥). type B was detected in three of eight pâté samples collected from the houses of cases. In the mouse bioassay for the toxicity of the pâté samples, all the mice died with clinical symptoms of botulism.
A tinned vegetarian pâté was the plausible cause of a botulism outbreak in Viet Nam in 2020. Revision of food safety regulations to improve quality control of tinned foods to prevent future outbreaks is recommended.
调查 2020 年越南多个省份发生的一起肉毒梭菌中毒事件的病因。
开展初步调查以确认暴发情况，并对潜在病因形成假设，随后对可能导致中毒的可疑食物进行病例对照评估。采集食物样本进行检测以确定病原体，并进行小鼠生物检测。采取控制措施以阻止疫情蔓延，并防止未来发生类似事件。
越南南部六个省份的 12 人被确诊患有肉毒梭菌中毒症状，其中 11 人病情危急需要呼吸支持。发病前 4 天所吃食物的历史表明，所有病例均食用了一种罐装素食肉酱，病例对照评估表明这与此次暴发显著相关，比值比为 35.2（95%置信区间：3.4-¥）。从病例家中采集的 8 份肉酱样本中，有 3 份检测到 B 型毒素。对肉酱样本进行的毒性小鼠生物检测中，所有小鼠均出现肉毒梭菌中毒的临床症状并死亡。
罐装素食肉酱是 2020 年越南发生的一起肉毒梭菌中毒事件的可能病因。建议修订食品安全法规，加强对罐装食品的质量控制，以防止未来再次发生此类事件。
