Acceleration of wound healing by topical application of gel formulation of (L.) Spreng kernel extract.

: Phytomedicines are gaining a spotlight in wound management, where much research has suggested the wound healing potential of . The objective of this study was to investigate the effectiveness of kernel extract in accelerating wound healing process in animal models. kernel was extracted using ethanol:water (7:3) solvent and was then used as a bioactive ingredient in a Carbopol 940-based gel formulation in four different concentrations (1, 3, 5 and 7 ppm). A 3 cm diameter wound was made in the dorsal area of rat and wound healing process was assessed up to 12 days using DESIGN (Depth, Exudate, Size of Inflammation/Infection, Granulation tissue, and Necrotic tissue) scoring system. Our data suggested that the DESIGN scores were significantly different among concentration groups after the 3 day onward suggesting extract accelerated the wound healing process. Rats treated with gel formulation containing 7 ppm of kernel extract had faster wound healing than that treated with topical Metcovazin. On day 6, macroscopic observation on 7 ppm group revealed that the wound had persistent redness, lesion area of < 3 cm , and 80% healthy granulation, where presence of exudate and redness were not observable. kernel extract was effective in accelerating wound healing on rats. Further study is warranted to purify the bioactive component and the action mechanism in wound healing process.