Gonzales Mitzi M, Wang Chen-Pin, Short Meghan I, Parent Danielle M, Kautz Tiffany, MacCarthy Daniel, Satizabal Claudia L, González David Andrés, Royall Donald R, Zare Habil, O'Bryant Sid, Maestre Gladys E, Tracy Russell P, Seshadri Sudha
Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases University of Texas Health Science Center San Antonio Texas USA.
Department of Neurology University of Texas Health Science Center San Antonio Texas USA.
Alzheimers Dement (Amst). 2022 Mar 24;14(1):e12298. doi: 10.1002/dad2.12298. eCollection 2022.
: The clinical translation of biofluid markers for dementia requires validation in diverse cohorts. The study goal was to evaluate if blood biomarkers reflecting diverse pathophysiological processes predict disease progression in Mexican American adults. : Mexican American adults (n = 745), 50 years of age and older, completed annual assessments over a mean of 4 years. Serum collected at baseline was assayed for total tau, neurofilament light (NFL), ubiquitin carboxyl-terminal hydrolase LI, glial fibrillary acidic protein (GFAP), soluble cluster of differentiation 14 (sCD14), and chitinase-3-like protein 1 (YKL-40). : Higher GFAP and NFL were associated with global cognitive decline. Only GFAP was associated with increased incident dementia risk (hazard ratio: 1.611 (95% confidence interval: 1.204-2.155)) and inclusion of additional biomarkers did not improve model fit. : Among a panel of six blood biomarkers previously associated with neurodegenerative disease, only GFAP predicted incident dementia in our cohort. The findings suggest that blood GFAP levels may aid dementia-risk prediction among Mexican American adults.
用于痴呆症的生物流体标志物的临床转化需要在不同队列中进行验证。本研究的目标是评估反映不同病理生理过程的血液生物标志物是否能预测墨西哥裔美国成年人的疾病进展。墨西哥裔美国成年人（n = 745），年龄在50岁及以上，平均4年完成一次年度评估。对基线时采集的血清检测总tau蛋白、神经丝轻链（NFL）、泛素羧基末端水解酶LI、胶质纤维酸性蛋白（GFAP）、可溶性分化簇14（sCD14）和几丁质酶3样蛋白1（YKL - 40）。较高的GFAP和NFL与整体认知能力下降有关。只有GFAP与痴呆症发病风险增加相关（风险比：1.611（95%置信区间：1.204 - 2.155）），纳入其他生物标志物并未改善模型拟合度。在先前与神经退行性疾病相关的一组六种血液生物标志物中，只有GFAP能预测我们队列中的痴呆症发病情况。研究结果表明，血液GFAP水平可能有助于预测墨西哥裔美国成年人的痴呆症风险。
