Endocrinology Department, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, China.
J Glob Health. 2022 Feb 19;12:05010. doi: 10.7189/jogh.12.05010. eCollection 2022.
In this study, we performed a bidirectional mendelian randomization analysis on circulating cytokines and critically ill COVID-19.
Both the exposure and outcome data were obtained from public genome wide association study (GWAS) database. We extracted independent instrumental variables from exposure at genome level significance ( < 5 × 10). Wald ratio or inverse variance weighted (IVW) method were used for estimating the causal relationships between circulating cytokines and critically ill COVID-19.
Only IL5 (cytokines to critically ill COVID-19 direction) and bNGF, IL8 (critically ill COVID-19 to cytokines direction) showed suggestive causal relations. However, these associations lost significance after FDR correction. Another validation data set of critically ill COVID-19 did not confirm these associations, either.
Our Mendelian randomization did not find causal relationships between analyzable circulating cytokines and critically ill COVID-19.
本研究对循环细胞因子与危重症 COVID-19 进行了双向孟德尔随机化分析。
暴露和结局数据均来自公开的全基因组关联研究（GWAS）数据库。我们从全基因组水平显著性（ < 5 × 10）的暴露中提取了独立的工具变量。采用 Wald 比或逆方差加权（IVW）法估计循环细胞因子与危重症 COVID-19 之间的因果关系。
仅 IL5（细胞因子向危重症 COVID-19 方向）和 bNGF、IL8（危重症 COVID-19 向细胞因子方向）显示出有意义的因果关系。然而，这些关联在 FDR 校正后失去了意义。危重症 COVID-19 的另一个验证数据集也没有证实这些关联。
我们的孟德尔随机化分析未发现可分析的循环细胞因子与危重症 COVID-19 之间存在因果关系。
