大蒜可抑制白色念珠菌的脂质合成。
Allium sativum (garlic) inhibits lipid synthesis by Candida albicans.
作者信息
Adetumbi M, Javor G T, Lau B H
出版信息
Antimicrob Agents Chemother. 1986 Sep;30(3):499-501. doi: 10.1128/AAC.30.3.499.
Abstract
The effect of aqueous garlic extract on the macromolecular synthesis of Candida albicans was studied. Protein and nucleic acid syntheses were inhibited to the same extent as growth, but lipid synthesis was completely arrested. Blockage of lipid synthesis is likely an important component of the anticandidal activity of garlic.
摘要
研究了大蒜水提取物对白色念珠菌大分子合成的影响。蛋白质和核酸合成受到的抑制程度与生长受到的抑制程度相同，但脂质合成完全停止。脂质合成的阻断可能是大蒜抗念珠菌活性的一个重要组成部分。
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本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Enzyme inhibition by allicin, the active principle of garlic.大蒜的活性成分蒜素对酶的抑制作用。
Biochem J. 1956 Jul;63(3):514-20. doi: 10.1042/bj0630514.
3
The effect of aqueous garlic extract on the growth of dermatophytes.
Int J Dermatol. 1980 Jun;19(5):285-7. doi: 10.1111/j.1365-4362.1980.tb00331.x.
4
Allium sativum (garlic)--a natural antibiotic.大蒜——一种天然抗生素。
Med Hypotheses. 1983 Nov;12(3):227-37. doi: 10.1016/0306-9877(83)90040-3.
5
Mosquito control with active principle of garlic, Allium sativum.以大蒜（蒜属植物）活性成分进行蚊虫控制。
J Econ Entomol. 1970 Aug;63(4):1172-5. doi: 10.1093/jee/63.4.1172.
6
Isolation and characterization of larvicidal principle of garlic.大蒜杀幼虫原理的分离与特性研究
Science. 1971 Dec 24;174(4016):1343-4. doi: 10.1126/science.174.4016.1343.
7
Lipids of Salmonella typhimurium and Escherichia coli: structure and metabolism.鼠伤寒沙门氏菌和大肠杆菌的脂质：结构与代谢
J Bacteriol. 1968 Mar;95(3):833-43. doi: 10.1128/jb.95.3.833-843.1968.
8
Mutants of Escherichia coli defective in membrane phospholipid synthesis: macromolecular synthesis in an sn-glycerol 3-phosphate acyltransferase Km mutant.膜磷脂合成存在缺陷的大肠杆菌突变体：sn-甘油-3-磷酸酰基转移酶Km突变体中的大分子合成
J Bacteriol. 1974 Mar;117(3):1065-76. doi: 10.1128/jb.117.3.1065-1076.1974.
9
Inhibition of mycobacteria by garlic extract (Allium sativum).大蒜提取物（大蒜）对分枝杆菌的抑制作用。
Antimicrob Agents Chemother. 1985 Apr;27(4):485-6. doi: 10.1128/AAC.27.4.485.
10
Right to health.健康权。
Nouv Com Int Cathol Infirm Assist Med Soc. 1986(2-3):73-6.
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