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一种基于深度学习的小儿骨盆X线片评估发育性髋关节发育不良的辅助诊断系统。

A Deep-Learning Aided Diagnostic System in Assessing Developmental Dysplasia of the Hip on Pediatric Pelvic Radiographs.

作者信息

Xu Weize, Shu Liqi, Gong Ping, Huang Chencui, Xu Jingxu, Zhao Jingjiao, Shu Qiang, Zhu Ming, Qi Guoqiang, Zhao Guoqiang, Yu Gang

机构信息

The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

National Clinical Research Center for Child Health, Hangzhou, China.

出版信息

Front Pediatr. 2022 Mar 8;9:785480. doi: 10.3389/fped.2021.785480. eCollection 2021.

Abstract

BACKGROUND

Developmental dysplasia of the hip (DDH) is a common orthopedic disease in children. In clinical surgery, it is essential to quickly and accurately locate the exact position of the lesion, and there are still some controversies relating to DDH status. We adopt artificial intelligence (AI) to solve the above problems.

METHODS

In this paper, automatic DDH measurements and classifications were achieved using a three-stage pipeline. In the first stage, we used Mask-RCNN to detect the local features of the image and segment the bony pelvis, including the ilium, pubis, ischium, and femoral heads. For the second stage, local image patches focused on semantically related areas for DDH landmarks were extracted by high-resolution network (HRNet). In the third stage, some radiographic results are obtained. In the above process, we used 1,265 patient x-ray samples as the training set and 133 samples from two other medical institutions as the verification set. The results of AI were compared with three orthopedic surgeons for reliability and time consumption.

RESULTS

AI-aided diagnostic system's Tönnis and International Hip Dysplasia Institute (IHDI) classification accuracies for both hips ranged from 0.86 to 0.95. The measurements of numerical indices showed that there was no statistically significant difference between surgeons and AI. Tönnis and IHDI indicators were similar across the AI system, intermediate surgeon, and junior surgeon. Among some objective interpretation indicators, such as acetabular index and CE angle, there were good stability and consistency among the four observers. Intraclass consistency of acetabular index and CE angle among surgeons was 0.79-0.98, while AI was 1.00. The measurement time required by AI was significantly less than that of the doctors.

CONCLUSION

The AI-aided diagnosis system can quickly and automatically measure important parameters and improve the quality of clinical diagnosis and screening referral process with a convenient and efficient way.

摘要

背景

发育性髋关节发育不良(DDH)是儿童常见的骨科疾病。在临床手术中,快速准确地定位病变的确切位置至关重要,并且关于DDH状态仍存在一些争议。我们采用人工智能(AI)来解决上述问题。

方法

本文使用一个三阶段流程实现了DDH的自动测量和分类。在第一阶段,我们使用Mask-RCNN检测图像的局部特征并分割骨盆骨,包括髂骨、耻骨、坐骨和股骨头。在第二阶段,通过高分辨率网络(HRNet)提取专注于DDH标志语义相关区域的局部图像块。在第三阶段,获得一些影像学结果。在上述过程中,我们使用1265例患者的X线样本作为训练集,并使用来自其他两家医疗机构的133个样本作为验证集。将AI的结果与三位骨科医生的结果在可靠性和耗时方面进行比较。

结果

AI辅助诊断系统对双髋的Tönnis和国际髋关节发育不良协会(IHDI)分类准确率在0.86至0.95之间。数值指标的测量表明,外科医生和AI之间没有统计学上的显著差异。Tönnis和IHDI指标在AI系统、中级外科医生和初级外科医生之间相似。在一些客观解释指标中,如髋臼指数和CE角,四位观察者之间具有良好的稳定性和一致性。外科医生之间髋臼指数和CE角的组内一致性为0.79 - 0.98,而AI为1.00。AI所需的测量时间明显少于医生。

结论

AI辅助诊断系统可以快速自动地测量重要参数,并以方便高效的方式提高临床诊断和筛查转诊过程的质量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/466b/8959123/5c2d51a953d2/fped-09-785480-g0001.jpg

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