Holm Ellen, Jacobsen Katja Kemp, de Lony Thea Bang, Lembeck Maurice, Pedersen Hanne, Andersson Charlotte, Johannsen Peter, Jørgensen Terese Sara Høj, Torp-Pedersen Christian
Department of Internal Medicine University Hospital Zealand Køge Denmark.
Department of Clinical Medicine University of Copenhagen Copenhagen Denmark.
Alzheimers Dement (N Y). 2022 Mar 24;8(1):e12271. doi: 10.1002/trc2.12271. eCollection 2022.
Underdetection of dementia in areas with low socioeconomic status (SES) may interfere with findings concerning associations between SES and dementia.
Using administrative registers we assessed the associations between age- and sex-adjusted dementia incidence and neighborhood socioeconomic status (nSES) in 94 Danish municipalities. Wealth was divided into income quartiles and other nSES variables were dichotomized into high versus low according to the median.
High population density (odds ratio [OR] 1.21, 95% confidence interval [CI] 1.18-1.24), higher proportion of inhabitants in higher income quartiles ( for trend < .0001), and high educational level (OR 1.19, 95% CI 1.15-1.22) were associated with higher incidence of dementia. High proportion of residents above 65 years was associated with lower age-adjusted dementia incidence (OR 0.86, 95% CI 0.84-0.89).
Low nSES municipalities have a lower age-adjusted incidence of dementia diagnosis. These findings corroborate prior concerns that a large number of dementia diagnoses may be missed in municipalities characterized by low SES.
在社会经济地位（SES）较低的地区，痴呆症的漏检可能会影响有关SES与痴呆症之间关联的研究结果。
我们利用行政登记册评估了丹麦94个市中年龄和性别调整后的痴呆症发病率与邻里社会经济地位（nSES）之间的关联。财富被分为收入四分位数，其他nSES变量根据中位数分为高与低两类。
高人口密度（优势比[OR]1.21，95%置信区间[CI]1.18 - 1.24）、较高收入四分位数的居民比例较高（趋势P <.0001）以及高教育水平（OR 1.19，95% CI 1.15 - 1.22）与较高的痴呆症发病率相关。65岁以上居民比例较高与年龄调整后的痴呆症发病率较低相关（OR 0.86，95% CI 0.84 - 0.89）。
nSES较低的市年龄调整后的痴呆症诊断发病率较低。这些发现证实了之前的担忧，即在以低SES为特征的市中可能会漏诊大量痴呆症病例。
