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髋部骨折术后小腿肌间静脉丛孤立性深静脉血栓形成的发生率及危险因素。

Incidence and risk factors of preoperative isolated calf deep venous thrombosis following hip fractures.

机构信息

Department of Orthopaedic Surgery, Handan Central Hospital, Handan, Hebei, People's Republic of China.

Graduate School of Hebei North University, Zhangjiakou, Hebei, People's Republic of China.

出版信息

Medicine (Baltimore). 2022 Mar 25;101(12):e29140. doi: 10.1097/MD.0000000000029140.

Abstract

There is still a lack of data on isolated calf deep vein thrombosis (ICDVT) following hip fractures surgery. The study aimed to determine the incidence of preoperative ICDVT and the associated risk factors in patients with hip fractures requiring surgery.The 289 patients who required hip surgery were included, duplex ultrasonography was routinely used to make a definite diagnosis of preoperative ICDVT located in unilateral or bilateral calf. Data on demographics and laboratory-associated blood biomarkers results were included. Univariate analyses were used to analyse the data of demographics, comorbidities, personal history operation related indexes and laboratory biomarkers, then the multivariate logistic regression analysis was employed to identify the independent risk factors associated with ICDVT.Sixty-eight (23.5%) patients were diagnosed with preoperative ICDVTs. The univariate analyses showed significant differences regarding ICDVT were age, current smoking, alcohol consumption, time from injury to operation, albumin, white blood cells, lymphocyte, red blood cells, hemoglobin, hematocrit, and activated partial thromboplastin time level among the 44 factors. The multivariable model confirmed 3 risk factors were significantly independent in association with preoperative ICDVTs, including current smoking, time delay from injury to operation and activated partial thromboplastin time ( < 28seconds).The incidence of preoperative ICDVT in hip fracture was 23.5%, and patients with associated risk factors are prone to form ICDVTs, identification of these factors may help to reduce the incidence of ICDVT with hip fractures by taking early prevention measures.

摘要

术后孤立性小腿深静脉血栓形成(ICDVT)的数据仍然缺乏。本研究旨在确定需要手术的髋部骨折患者术前 ICDVT 的发生率和相关危险因素。

纳入了 289 名需要髋关节手术的患者,常规使用双功超声对单侧或双侧小腿的术前 ICDVT 进行明确诊断。纳入了人口统计学和与实验室相关的血液生物标志物结果的数据。使用单变量分析来分析人口统计学、合并症、个人史手术相关指标和实验室生物标志物数据,然后使用多变量逻辑回归分析来确定与 ICDVT 相关的独立危险因素。68 例(23.5%)患者术前诊断为 ICDVT。单变量分析显示,在年龄、当前吸烟、饮酒、受伤至手术的时间、白蛋白、白细胞、淋巴细胞、红细胞、血红蛋白、血细胞比容和活化部分凝血活酶时间水平等 44 个因素中,ICDVT 存在显著差异。多变量模型证实 3 个危险因素与术前 ICDVT 显著独立相关,包括当前吸烟、受伤至手术的时间延迟和活化部分凝血活酶时间(<28 秒)。

髋部骨折患者术前 ICDVT 的发生率为 23.5%,伴有相关危险因素的患者容易形成 ICDVT,识别这些因素可能有助于通过早期预防措施降低髋部骨折 ICDVT 的发生率。

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