Bahamas Vision Centre and Princess Margaret Hospital, Nassau NP, Bahamas.
UPMC Eye Center, University of Pittsburgh, Pittsburgh, PA, USA.
Graefes Arch Clin Exp Ophthalmol. 2022 Aug;260(8):2475-2481. doi: 10.1007/s00417-022-05636-3. Epub 2022 Mar 31.
To study the regression patterns of subretinal fluid (SRF) in central serous chorioretinopathy (CSCR) on sequential en face optical coherence tomography (OCT) and its relationship to leak locations.
Retrospective study on patients with acute CSCR. Inclusion criteria were (i) availability of data, sequential OCT and OCT angiography (B scan and en face OCT) every 2 weeks until resolution of SRF or 6 months, whichever is earlier; (ii) single active leak. Exclusion criteria were (i) presence of macular neovascularization or atypical CSCR, (ii) diffuse pigment epitheliopathy, (iii) multiple leaks. Serial en face OCT scans were evaluated and the area of SRF was measured using ImageJ software. Correlation coefficient was calculated for the regression rate of SRF area and central retinal thickness (CRT) over the first month of follow-up and the time of complete SRF resolution.
Out of the 25 eyes, 20 eyes demonstrated a centripetal regression, and 5 eyes demonstrated a centrifugal regression. In eyes with a leakage point <1000μ from the fovea, 86% resolved in a centripetal fashion, and in eyes with leak site ≥1000μ away from fovea, 70% eyes resolved centripetally. There was a correlation (r=-0.47, p=0.018) of the rate regression of SRF area during the first month and timing of resolution. In contrast, this correlation was absent (r=-0.16, p=0.44) for CRT regression.
Our en face-based analysis of sequential OCTs of regressing CSCR demonstrated a tendency for the subfoveal SRF to resolve towards the end or a centripetal pattern of regression. Prediction of resolution of SRF at 1 month is better with en face area of SRF in comparison to CRT.
研究中心性浆液性脉络膜视网膜病变（CSCR）中视网膜下液（SRF）在序贯面光学相干断层扫描（OCT）上的消退模式及其与渗漏部位的关系。
回顾性研究急性 CSCR 患者。纳入标准为：（i）数据可用，每 2 周进行一次 SRF 连续 OCT 和 OCT 血管造影（B 扫描和面 OCT），直至 SRF 消退或 6 个月，以先发生者为准；（ii）单个活跃渗漏。排除标准为：（i）存在黄斑新生血管或非典型 CSCR；（ii）弥漫性色素上皮病变；（iii）多个渗漏。对面 OCT 扫描进行评估，并使用 ImageJ 软件测量 SRF 面积。计算 SRF 面积和中央视网膜厚度（CRT）在随访第 1 个月的消退率以及完全消退 SRF 的时间的相关系数。
在 25 只眼中，20 只眼表现为向心性消退，5 只眼表现为离心性消退。在距黄斑<1000μ 的渗漏点处，86%的眼以向心性方式消退，而在距黄斑≥1000μ 的渗漏点处，70%的眼以向心性方式消退。在第 1 个月内 SRF 面积的消退率与消退时间之间存在相关性（r=-0.47，p=0.018）。相比之下，CRT 消退的相关性不存在（r=-0.16，p=0.44）。
我们对面 OCT 对 CSCR 消退的连续分析显示，亚黄斑 SRF 有向终末或向心性消退的趋势。与 CRT 相比，用 SRF 面面积预测第 1 个月的 SRF 消退情况更好。
