Department of Plastic and Reconstructive Surgery, Wonju Severance Christian Hospital, Wonju College of Medicine, Yonsei University, Wonju, Republic of Korea.
Department of Dermatology, Wonju Severance Christian Hospital, Wonju College of Medicine, Yonsei University, Wonju, Republic of Korea.
Aesthetic Plast Surg. 2022 Aug;46(4):1902-1909. doi: 10.1007/s00266-022-02832-8. Epub 2022 Mar 31.
Dermal fillers are gaining interest for tissue enlargement and skin improvement. Among them, polynucleotides have demonstrated multiple skin beneficial effects. The effects of polynucleotide fillers were objectively evaluated using an Antera 3D camera, subjectively evaluated by participants and investigators.
Thirty subjects with crow's feet were enrolled in the study. The subjects received polynucleotide filler for crow's feet. Crow's feet grading score (CFGS), global esthetic improvement scale (GAIS), and Antera 3D imaging results were evaluated.
Twenty-eight subjects (93.3%) completed the study. An improvement in CFGS compared with that at baseline (p < 0.001) was observed 18 weeks after the first injection of polynucleotides. Additionally, at the final visit, there were improvements in wrinkle, texture, pore, depression, and Hb values compared with those at baseline (p < 0.05). However, no significant difference in melanin level was detected between the initial and final visits.
Improvements in wrinkles, pores, texture, depression, and Hb level after polynucleotide filler injection were verified by objective and subjective evaluations. To the best of our knowledge, this is the first report on the objective evaluation of polynucleotide fillers in crow's feet using the Antera 3D camera.
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真皮填充剂在组织增大和皮肤改善方面的应用越来越受到关注。其中，多核苷酸已显示出多种皮肤有益效果。本研究使用 Antera 3D 相机客观评估、参与者和研究者主观评估多核苷酸填充剂的效果。
纳入 30 名鱼尾纹患者，给予多核苷酸填充剂治疗鱼尾纹。评估鱼尾纹分级评分（CFGS）、整体美学改善量表（GAIS）和 Antera 3D 成像结果。
28 名患者（93.3%）完成了研究。与基线相比，第一次注射多核苷酸 18 周后 CFGS 显著改善（p < 0.001）。此外，在最后一次就诊时，皱纹、纹理、毛孔、凹陷和 Hb 值与基线相比均有改善（p < 0.05）。然而，初始和最终就诊时黑素水平无显著差异。
通过客观和主观评估证实了多核苷酸填充剂注射后皱纹、毛孔、纹理、凹陷和 Hb 水平的改善。据我们所知，这是首次使用 Antera 3D 相机对鱼尾纹中多核苷酸填充剂进行的客观评估报告。
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