Lampridou Smaragda, Bassett Sian, Cavallini Maurizio, Christopoulos George
Department of Surgery and Cancer, Imperial College London, London, UK.
Sian Aesthetics, Highgate, London, UK.
J Cosmet Dermatol. 2025 Feb;24(2):e16721. doi: 10.1111/jocd.16721. Epub 2024 Dec 8.
Polynucleotides (PN), popular in biorevitalization, show promise in the current sphere of esthetic medicine due to their regenerative properties, previously used in wound healing. Currently, research investigates their use in esthetic medicine. The aim of this review was to synthesize the existing literature, focusing on the effectiveness of PN in esthetic medicine, which is concentrated on skin rejuvenation by providing patients with multiple benefits and the least side effects.
A systematic electronic search was conducted in Embase, Medline, and Cochrane to identify primary research studies evaluating the effectiveness of polynucleotides in esthetic medicine, published in English between January 01, 2010, and January 01, 2024. A narrative synthesis was reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. The quality of evidence was assessed using the Critical Appraisal Skills Programme checklists. PROSPERO Registration: CRD42024588712.
Nine studies, of low and moderate quality, were included in this review, describing a population of 219 patients receiving PN treatment. A variation was present regarding procedural characteristics, such as injection areas and techniques. Polynucleotide injections have shown promising outcomes in reducing wrinkles, improving skin texture, and enhancing elasticity, with statistically significant results in several studies. While side effects are generally mild and transient, patient satisfaction is moderate to high, suggesting PN treatment as a well-tolerated and effective cosmetic intervention.
Polynucleotides offer promising potential in esthetic medicine; however, there is limited consensus regarding their optimal use. Rigorous, high-quality studies are essential to validate the effectiveness and safety of PN.
多核苷酸（PN）在生物焕活领域颇受欢迎，因其具有再生特性，此前用于伤口愈合，在当前美容医学领域显示出应用前景。目前，有研究对其在美容医学中的应用进行调查。本综述的目的是综合现有文献，聚焦多核苷酸在美容医学中的有效性，其主要通过为患者提供多种益处且副作用最小来实现皮肤年轻化。
在Embase、Medline和Cochrane数据库中进行系统的电子检索，以识别评估多核苷酸在美容医学中有效性的原始研究，这些研究发表于2010年1月1日至2024年1月1日之间，语言为英文。根据系统评价和Meta分析的首选报告项目声明进行叙述性综合分析。使用关键评估技能计划清单评估证据质量。PROSPERO注册号：CRD42024588712。
本综述纳入了9项质量低至中等的研究，共描述了219例接受PN治疗的患者。在操作特征方面存在差异，如注射部位和技术。多核苷酸注射在减少皱纹、改善皮肤质地和增强弹性方面显示出有前景的结果，多项研究结果具有统计学意义。虽然副作用一般较轻且为短暂性，但患者满意度为中度至高，表明PN治疗是一种耐受性良好且有效的美容干预措施。
多核苷酸在美容医学中具有有前景的潜力；然而，关于其最佳使用方法的共识有限。严格、高质量的研究对于验证PN的有效性和安全性至关重要。
