Department of Biomedical Sciences, School of Bio Sciences and Technology, Vellore Institute of Technology (VIT), Vellore, Tamil Nadu 632014, India.
Department of Biomedical Sciences, School of Bio Sciences and Technology, Vellore Institute of Technology (VIT), Vellore, Tamil Nadu 632014, India; Centre of Molecular Medicine and Diagnostics (COMManD), Department of Biochemistry, Saveetha Dental College & Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, 600077 Tamil Nadu, India.
Environ Toxicol Pharmacol. 2022 May;92:103859. doi: 10.1016/j.etap.2022.103859. Epub 2022 Mar 28.
Heavy metals and metalloid exposure are among the most common factors responsible for reproductive toxicity in human beings. Several studies have indicated that numerous metals and metalloids can display severe adverse properties on the human reproductive system. Metals like lead, silver, cadmium, uranium, vanadium, and mercury and metalloids like arsenic have been known to induce reproductive toxicity. Moderate to minute quantities of lead may affect several reproductive parameters and even affect semen quality. The ecological and industrial exposures to the various heavy metals and metalloids have disastrous effects on the reproductive system ensuing in infertility. This work emphasizes the mechanism and pathophysiology of the aforementioned heavy metals and metalloids in reproductive toxicity. Additionally, this work aims to cover the classical protective mechanisms of zinc, melatonin, chelation therapy, and other trending methods to prevent heavy metal-induced reproductive toxicity.
重金属和类金属暴露是导致人类生殖毒性的最常见因素之一。有几项研究表明，许多金属和类金属对人类生殖系统可能表现出严重的不良特性。已知铅、银、镉、铀、钒和汞等金属以及砷等类金属会引起生殖毒性。中等至微量的铅可能会影响几个生殖参数，甚至影响精液质量。各种重金属和类金属在生态和工业方面的暴露对生殖系统造成了灾难性的影响，导致不孕。这项工作强调了上述重金属和类金属在生殖毒性中的作用机制和病理生理学。此外，这项工作旨在涵盖锌、褪黑素、螯合疗法和其他预防重金属诱导的生殖毒性的热门方法的经典保护机制。
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