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First pig-to-human heart transplantation.

作者信息

Wang Wei, He Wenbo, Ruan Yongle, Geng Qing

机构信息

Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China.

Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China.

出版信息

Innovation (Camb). 2022 Mar 7;3(2):100223. doi: 10.1016/j.xinn.2022.100223. eCollection 2022 Mar 29.

DOI:10.1016/j.xinn.2022.100223
PMID:35359338
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8961469/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f09/8961469/70039de30e95/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f09/8961469/70039de30e95/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f09/8961469/70039de30e95/gr1.jpg

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1
First pig-to-human heart transplantation.首例猪到人的心脏移植手术。
Innovation (Camb). 2022 Mar 7;3(2):100223. doi: 10.1016/j.xinn.2022.100223. eCollection 2022 Mar 29.
2
Report of the Xenotransplantation Advisory Committee of the International Society for Heart and Lung Transplantation: the present status of xenotransplantation and its potential role in the treatment of end-stage cardiac and pulmonary diseases.国际心肺移植学会异种移植咨询委员会报告:异种移植的现状及其在终末期心脏和肺部疾病治疗中的潜在作用。
J Heart Lung Transplant. 2000 Dec;19(12):1125-65. doi: 10.1016/s1053-2498(00)00224-2.
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Hyperacute rejection of hDAF-transgenic pig organ xenografts in cynomolgus monkeys: influence of pre-existing anti-pig antibodies and prevention by the alpha GAL glycoconjugate GAS914.食蟹猴中hDAF转基因猪器官异种移植的超急性排斥反应:预先存在的抗猪抗体的影响以及α-半乳糖糖缀合物GAS914的预防作用
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Soluble Galalpha(1,3)Gal conjugate combined with hDAF preserves morphology and improves function of cardiac xenografts.可溶性半乳糖α(1,3)半乳糖共轭物与人类衰变加速因子结合可保留心脏异种移植物的形态并改善其功能。
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Heart Xenotransplantation: Historical Background, Experimental Progress, and Clinical Prospects.心脏异种移植:历史背景、实验进展及临床前景
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[Anatomy of heart in banna mini-pig inbred-lines].[版纳微型猪近交系心脏的解剖学]
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2003 Jan;17(1):69-72.
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Cureus. 2025 Aug 29;17(8):e91236. doi: 10.7759/cureus.91236. eCollection 2025 Aug.
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Baseline Characterization of Swine Leukocyte Antigen Diversity in GFP-Expressing Domestic Swine.表达绿色荧光蛋白的家猪中猪白细胞抗原多样性的基线特征分析
J Am Assoc Lab Anim Sci. 2025 Jun 1;64(4):1-8. doi: 10.30802/AALAS-JAALAS-25-022.
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Reshaping transplantation with AI, emerging technologies and xenotransplantation.

本文引用的文献

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Immune and Genome Engineering as the Future of Transplantable Tissue.免疫与基因组工程作为可移植组织的未来发展方向
N Engl J Med. 2021 Dec 23;385(26):2451-2462. doi: 10.1056/NEJMra1913421.
2
Humoral Reactivity of Renal Transplant-Waitlisted Patients to Cells From GGTA1/CMAH/B4GalNT2, and SLA Class I Knockout Pigs.等待肾移植患者对GGTA1/CMAH/B4GalNT2和SLA I类基因敲除猪细胞的体液反应性。
Transplantation. 2017 Apr;101(4):e86-e92. doi: 10.1097/TP.0000000000001646.
3
Prolonged Survival of Pig Skin on Baboons After Administration of Pig Cells Expressing Human CD47.
利用人工智能、新兴技术和异种移植重塑移植领域。
Nat Med. 2025 Jul 14. doi: 10.1038/s41591-025-03801-9.
4
Insights into the history and tendency of cardiac transplantation for heart failure: A bibliometric-based visual analysis.心力衰竭心脏移植的历史与趋势洞察:基于文献计量学的可视化分析
Int J Cardiol Heart Vasc. 2025 May 1;59:101691. doi: 10.1016/j.ijcha.2025.101691. eCollection 2025 Aug.
5
Perceptions and Attitudes of Muslims in Israel When Using Porcine-Based Organs in Transplantation Procedures.以色列穆斯林在移植手术中使用猪源器官时的认知与态度。
J Relig Health. 2025 May 13. doi: 10.1007/s10943-025-02327-1.
6
Swine clones: potential application for animal production and animal models.猪克隆:在动物生产和动物模型中的潜在应用。
Anim Reprod. 2025 Jan 20;22(1):e20240037. doi: 10.1590/1984-3143-AR2024-0037. eCollection 2025.
7
Comparative pharmacokinetics of porcine and human anti-influenza hemagglutinin monoclonal antibodies in outbred pigs and minipigs.猪和小型猪中外源抗流感血凝素单克隆抗体的比较药代动力学。
Front Immunol. 2024 Oct 31;15:1471412. doi: 10.3389/fimmu.2024.1471412. eCollection 2024.
8
When will dual-purpose pigs fly?两用猪什么时候会飞?
Innovation (Camb). 2024 Sep 6;5(6):100702. doi: 10.1016/j.xinn.2024.100702. eCollection 2024 Nov 4.
9
Angiogenic properties and intercellular communication of differentiated porcine endothelial cells in vascular therapy.血管治疗中分化猪内皮细胞的血管生成特性和细胞间通讯。
Sci Rep. 2024 Oct 1;14(1):22844. doi: 10.1038/s41598-024-73584-5.
10
Editorial: Precision therapeutics using next generation technologies in transplantation.社论:移植中使用下一代技术的精准治疗
Front Transplant. 2024 Mar 7;3:1371701. doi: 10.3389/frtra.2024.1371701. eCollection 2024.
给予表达人CD47的猪细胞后猪皮肤在狒狒身上的长期存活
Transplantation. 2017 Feb;101(2):316-321. doi: 10.1097/TP.0000000000001267.
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Evaluation of human and non-human primate antibody binding to pig cells lacking GGTA1/CMAH/β4GalNT2 genes.评估人类和非人灵长类动物抗体与缺乏GGTA1/CMAH/β4GalNT2基因的猪细胞的结合情况。
Xenotransplantation. 2015 May-Jun;22(3):194-202. doi: 10.1111/xen.12161. Epub 2015 Mar 1.
5
[Heart transplantation in childhood: heredity of Baby Fae].[儿童心脏移植:“宝宝菲”的遗传情况]
G Ital Cardiol. 1996 Mar;26(3):353-5.