Brodin Alvin T S, Gabulya Sarolta, Wellfelt Katrin, Karlsson Tobias E
Department of Neuroscience, Karolinska Institutet, Solna, Sweden.
Institute of Neuroinformatics, University of Zurich and ETH, Zürich, Switzerland.
Front Synaptic Neurosci. 2022 Mar 14;14:854160. doi: 10.3389/fnsyn.2022.854160. eCollection 2022.
Sleep is essential for long term memory function. However, the neuroanatomical consequences of sleep loss are disputed. Sleep deprivation has been reported to cause both decreases and increases of dendritic spine density. Here we use Thy1-GFP expressing transgenic mice to investigate the effects of acute sleep deprivation on the dendritic architecture of hippocampal CA1 pyramidal neurons. We found that 5 h of sleep deprivation had no effect on either dendritic length or dendritic spine density. Our work suggests that no major neuroanatomical changes result from a single episode of sleep deprivation.
睡眠对于长期记忆功能至关重要。然而，睡眠缺失的神经解剖学后果存在争议。据报道，睡眠剥夺会导致树突棘密度降低和增加。在这里，我们使用表达Thy1-GFP的转基因小鼠来研究急性睡眠剥夺对海马CA1锥体神经元树突结构的影响。我们发现，5小时的睡眠剥夺对树突长度或树突棘密度均无影响。我们的研究表明，单次睡眠剥夺不会导致重大的神经解剖学变化。
