Bharat Krish Tejas, Manhas Navdeep Singh, Gutcho James, Lin Joshua, Bhattacharyya Sumon, Kounang Robertus
California University of Science and Medicine, Colton, CA, USA.
Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Clin Med Insights Arthritis Musculoskelet Disord. 2022 Mar 25;15:11795441211063365. doi: 10.1177/11795441211063365. eCollection 2022.
Osteoarthritis is a prevalent degenerative disease affecting a large portion of the world's aging population. Currently, nonsteroidal anti-inflammatory drugs and acetaminophen are first-line medications for treating osteoarthritis patients' pain. However, several studies have noted that while these medications control pain they do not halt progressive degeneration and tend to have an unfavorable side-effect profile with prolonged use. Recently, due to their more favorable side-effect profiles, herbal alternatives for controlling osteoarthritis symptoms and for alleviating the progression of the disease are being increasingly studied. Synogesic is a newly developed herbal supplement blend by renowned orthopedic surgeons and physiatrists consisting of turmeric, rutin, ginger root, vitamin C, vitamin D, and boswellia extracts. A study by Sharkey et al. has commented on the efficacy of the blend on the patients with knee osteoarthritis. So far, a review on the ingredients of the blend has not yet carried outbeen. By exploring prominent literature databases including PubMed and ScienceDirect, our aim is to write a narrative review to explore the individual ingredients of this blend and delve into their characteristics, as well as the most recent literature on their mechanism and efficacy in patients with osteoarthritis. Through this, we hope to inform clinicians and patients alike on relevant up-to-date research on the supplement and provide insight on the potential for this supplement for alleviating the disease course of patients with osteoarthritis.
骨关节炎是一种普遍的退行性疾病，影响着世界上很大一部分老年人口。目前，非甾体抗炎药和对乙酰氨基酚是治疗骨关节炎患者疼痛的一线药物。然而，多项研究指出，虽然这些药物能控制疼痛，但并不能阻止病情的逐渐恶化，而且长期使用往往会产生不良副作用。最近，由于其副作用较小，用于控制骨关节炎症状和缓解疾病进展的草药替代品正受到越来越多的研究。Synogesic是由著名骨科医生和物理治疗师新开发的一种草药补充剂，由姜黄、芦丁、生姜根、维生素C、维生素D和乳香提取物组成。Sharkey等人的一项研究评论了该混合物对膝骨关节炎患者的疗效。到目前为止，尚未对该混合物的成分进行综述。通过探索包括PubMed和ScienceDirect在内的著名文献数据库，我们的目的是撰写一篇叙述性综述，探讨该混合物的各个成分，深入研究它们的特性，以及关于它们在骨关节炎患者中的作用机制和疗效的最新文献。通过这篇综述，我们希望向临床医生和患者通报有关该补充剂的最新研究情况，并深入了解该补充剂缓解骨关节炎患者病程的潜力。
