School of Foreign Languages, Harbin University of Science and Technology, Harbin, Heilongjiang 150080, China.
Faculty of Neurological Rehabilitation, Heilongjiang Rehabilitation Hospital, Harbin, Heilongjiang 150028, China.
Contrast Media Mol Imaging. 2022 Mar 20;2022:5885860. doi: 10.1155/2022/5885860. eCollection 2022.
A total of 35 patients with aphasia after cerebral infarct were included. Among them, 15 conjunctures were sensory (Wernicke's) aphasia and 20 cases were motor (Broca) aphasia. Perfusion Weighted Imaging (PWI) and Magnetic Resonance Spectroscopy (MRS) were performed on the attached hard area to measure the local cerebral blood flow (rCBF) and sectional cerebral blood compass (rCBV), mean conveyance tense (MTT), point delay (TTP), and -acetylaspartate (NAA), choline (Cho), creatine (Cr)), and lactic acidic (lactate, Lac) and generally a relative analysis. . Among the patients with contaminative aphasia, rCBF was way diminished in the contralateral mirror extent. MTT and TTP were significantly longer than the contralateral mirror range, NAA and Cho were sullenness than the contralateral side, and the Lac peak appeared. The distinction was statistically taken ( < 0.05). Compared with the contralateral mirror circumference, motor aphasia was significantly reduced in rCBF and rCBV, and MTT and TTP were way prolonged. NAA and Cho were reduced compared with the contralateral side, and the Lac peak appeared. The dispute was statistically momentous ( < 0.05). . After cerebral infarction, the language cosine extent of patients with aphasia bestows a rank of hypoperfusion and light metabolism, suggesting that it may be the pathogeny of aphasia.
共纳入 35 例脑梗死后失语症患者。其中,15 例为感觉性(Wernicke 失语症)失语症,20 例为运动性(Broca 失语症)失语症。对附加硬区进行灌注加权成像(PWI)和磁共振波谱(MRS)检查,测量局部脑血流量(rCBF)和分节脑血容量(rCBV)、平均传输时间(MTT)、点延迟(TTP)、-乙酰天门冬氨酸(NAA)、胆碱(Cho)、肌酸(Cr),并进行一般相对分析。在混合性失语症患者中,对侧镜像区 rCBF 明显减少。MTT 和 TTP 明显长于对侧镜像范围,NAA 和 Cho 低于对侧,出现 Lac 峰。差异具有统计学意义( < 0.05)。与对侧镜像区相比,运动性失语症 rCBF 和 rCBV 明显减少,MTT 和 TTP 明显延长。NAA 和 Cho 较对侧减少,出现 Lac 峰。差异具有统计学意义( < 0.05)。脑梗死发生后,失语症患者语言相关区存在低灌注、轻代谢程度分级,提示可能是失语症的发病机制。