Vidovic Srdjan, Stojkovska Jasmina, Stevanovic Milan, Balanc Bojana, Vukasinovic-Sekulic Maja, Marinkovic Aleksandar, Obradovic Bojana
Faculty of Technology and Metallurgy, University of Belgrade, 11000 Belgrade, Serbia.
Innovation Center of the Faculty of Technology and Metallurgy, 11000 Belgrade, Serbia.
R Soc Open Sci. 2022 Mar 30;9(3):211517. doi: 10.1098/rsos.211517. eCollection 2022 Mar.
In this work, nanocomposite fibres and microfibres based on alginate and poly(vinyl alcohol) (PVA) with silver nanoparticles (AgNPs) were produced and characterized for potential application as antibacterial wound dressings. PVA/Ag/Na-alginate colloid solution was used for the preparation of the fibres by a simple extrusion technique followed by freezing-thawing cycles. UV-Visible spectroscopy confirmed successful preservation of AgNPs in fibres while Fourier transform infrared spectroscopy has shown a balanced combined effect on the Ca-alginate spatial arrangement with the addition of both AgNPs and PVA. The presence of PVA in fibres induced an increase in the swelling degree as compared with that of Ag/Ca-alginate fibres (approx. 28 versus approx. 14). Still, the initially produced PVA/Ca-alginate fibres were mechanically weaker than Ca-alginate fibres, but after drying and rehydration exhibited better mechanical properties. Also, the obtained fibres released AgNPs and/or silver ions at the concentration of approximately 2.6 µg cm leading to bacteriostatic effects against and . These results are relevant for practical utilization of the fibres, which could be stored and applied in the dry form with preserved mechanical stability, sorption capacity and antibacterial activity.
在这项工作中，制备了基于藻酸盐和聚乙烯醇（PVA）并含有银纳米颗粒（AgNPs）的纳米复合纤维和微纤维，并对其作为抗菌伤口敷料的潜在应用进行了表征。通过简单的挤压技术，随后进行冻融循环，使用PVA/Ag/Na-藻酸盐胶体溶液来制备纤维。紫外可见光谱证实了纤维中AgNPs的成功保留，而傅里叶变换红外光谱显示，添加AgNPs和PVA后，对钙藻酸盐的空间排列产生了平衡的综合影响。与Ag/Ca-藻酸盐纤维相比，纤维中PVA的存在导致溶胀度增加（约28对约14）。然而，最初制备的PVA/Ca-藻酸盐纤维在机械性能上比Ca-藻酸盐纤维弱，但在干燥和再水化后表现出更好的机械性能。此外，所获得的纤维以约2.6 µg/cm的浓度释放AgNPs和/或银离子，从而对[具体细菌1]和[具体细菌2]产生抑菌作用。这些结果与纤维的实际应用相关，纤维可以以干燥形式储存和应用，同时保持机械稳定性、吸附能力和抗菌活性。
