Linkas Jonas, Ahmed Luai Awad, Csifcsak Gabor, Emaus Nina, Furberg Anne-Sofie, Grimnes Guri, Pettersen Gunn, Rognmo Kamilla, Christoffersen Tore
Department of Health and Care Sciences, UiT The Arctic University of Norway, Narvik, Norway.
Institute of Public Health, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.
Front Psychol. 2022 Mar 11;13:823420. doi: 10.3389/fpsyg.2022.823420. eCollection 2022.
The scarcity of research on associations between inflammatory markers and symptoms of depression and anxiety during adolescence has yielded inconsistent results. Further, not all studies have controlled for potential confounders. We explored the associations between baseline inflammatory markers and psychological distress including moderators at follow-up in a Norwegian adolescent population sample.
Data was derived from 373 girls and 294 boys aged 15-18 years at baseline, in the Fit Futures Study, a large-scale 2-year follow-up study on adolescent health. Baseline data was gathered from 2010 to 2011 and follow-up data from 2012 to 2013. Psychological distress was measured with Hopkins Symptom Checklist (HSCL-10). Serum levels of the following inflammatory markers were measured: C-reactive protein (CRP), Interleukin 6 (IL-6), Transforming growth factor alpha (TGF-α), Tumor necrosis factor alpha variant 1 (TRANCE), and variant 2 (TWEAK). Independent associations between baseline inflammatory markers and HSCL-10 at follow-up were explored by linear regressions, in sex-stratified analyses.
In girls, analyses showed positive associations between all inflammatory markers and HSCL-10, except for TRANCE. However, all associations were non-significant in crude as well as in adjusted analyses. In boys, CRP ( = 0.03) and TGF-α ( < 0.01) showed significant associations with HSCL-10, that remained significant after adjustment. Additionally, moderators were found. In boys, CRP was associated with HSCL-10 in those with high body fat and those being physical inactive, and the association between TWEAK and HSCL-10 was dependent upon sleep duration.
There were significant prospective associations between CRP, TFG-α, and HSCL-10 in boys aged 15-18 years at baseline.
关于青少年时期炎症标志物与抑郁和焦虑症状之间关联的研究较少，结果也不一致。此外，并非所有研究都对潜在的混杂因素进行了控制。我们在挪威青少年人群样本中探讨了基线炎症标志物与心理困扰之间的关联，包括随访时的调节因素。
数据来自“健康未来研究”中基线年龄为15 - 18岁的373名女孩和294名男孩，这是一项关于青少年健康的大规模两年随访研究。基线数据收集于2010年至2011年，随访数据收集于2012年至2013年。心理困扰用霍普金斯症状清单（HSCL - 10）进行测量。测量了以下炎症标志物的血清水平：C反应蛋白（CRP）、白细胞介素6（IL - 6）、转化生长因子α（TGF - α）、肿瘤坏死因子α变体1（TRANCE）和变体2（TWEAK）。通过线性回归在按性别分层的分析中探讨基线炎症标志物与随访时HSCL - 10之间的独立关联。
在女孩中，分析显示除TRANCE外，所有炎症标志物与HSCL - 10之间均呈正相关。然而，在粗分析和调整分析中，所有关联均不显著。在男孩中，CRP（= 0.03）和TGF - α（< 0.01）与HSCL - 10显示出显著关联，调整后仍显著。此外，还发现了调节因素。在男孩中，CRP与高体脂和缺乏身体活动的男孩的HSCL - 10相关，TWEAK与HSCL - 10之间的关联取决于睡眠时间。
在基线年龄为15 - 18岁的男孩中，CRP、TFG - α与HSCL - 10之间存在显著的前瞻性关联。
