普萘洛尔对健康和临床样本记忆再巩固的损害作用：一项荟萃分析。
Impairing memory reconsolidation with propranolol in healthy and clinical samples: a meta-analysis.
机构信息
From McGill University, Montréal, Que., Canada (Pigeon, Lonergan, Rotondo, Brunet); the Douglas Mental Health University Institute Research Center, Montréal, Que., Canada (Pigeon, Lonergan, Rotondo, Brunet); the School of Psychology, University of Ottawa, Ottawa, Ont., Canada (Lonergan); and the Department of Psychiatry, Harvard Medical School, Charlestown, Mass., USA (Pitman).
From McGill University, Montréal, Que., Canada (Pigeon, Lonergan, Rotondo, Brunet); the Douglas Mental Health University Institute Research Center, Montréal, Que., Canada (Pigeon, Lonergan, Rotondo, Brunet); the School of Psychology, University of Ottawa, Ottawa, Ont., Canada (Lonergan); and the Department of Psychiatry, Harvard Medical School, Charlestown, Mass., USA (Pitman)
出版信息
J Psychiatry Neurosci. 2022 Mar 31;47(2):E109-E122. doi: 10.1503/jpn.210057. Print 2022 Mar-Apr.
BACKGROUND
Reconsolidation impairment using propranolol is a novel intervention for mental disorders with an emotional memory at their core. In this systematic review and meta-analysis, we examined the evidence for this intervention in healthy and clinical adult samples.
METHODS
We searched 8 databases for randomized, double-blind studies that involved at least 1 propranolol group and 1 placebo group. We conducted a meta-analysis of 14 studies ( = 478) in healthy adults and 12 studies in clinical samples ( = 446).
RESULTS
Compared to placebo, reconsolidation impairment under propranolol resulted in reduced recall of aversive material and cue-elicited conditioned emotional responses in healthy adults, as evidenced by an effect size (Hedges ) of -0.51 ( = 0.002, 2-tailed). Moreover, compared to placebo, reconsolidation impairment under propranolol alleviated psychiatric symptoms and reduced cue-elicited reactivity in clinical samples with posttraumatic stress disorder, addiction or phobia ( = -0.42, = 0.010).
LIMITATIONS
Methodological differences between studies posed an obstacle for identifying sources of heterogeneity.
CONCLUSION
Reconsolidation impairment is a robust, well-replicated phenomenon in humans. Its clinical use is promising and deserves further controlled investigation.
背景
使用普萘洛尔进行再巩固损伤是一种针对以情绪记忆为核心的精神障碍的新型干预措施。在这项系统评价和荟萃分析中，我们检查了该干预措施在健康和临床成年人群体中的证据。
方法
我们在 8 个数据库中搜索了至少包含 1 个普萘洛尔组和 1 个安慰剂组的随机、双盲研究。我们对 14 项健康成年人研究（n = 478）和 12 项临床样本研究（n = 446）进行了荟萃分析。
结果
与安慰剂相比，普萘洛尔下的再巩固损伤导致健康成年人对厌恶材料的回忆减少，以及线索诱发的条件情绪反应减少，这一证据体现在效应大小（Hedges ）为-0.51（p = 0.002，双侧）。此外，与安慰剂相比，普萘洛尔下的再巩固损伤减轻了创伤后应激障碍、成瘾或恐惧症患者的精神症状，并减少了线索诱发的反应性（ = -0.42，p = 0.010）。
局限性
研究之间的方法学差异为识别异质性的来源带来了障碍。
结论
再巩固损伤是人类中一种强大且经过良好复制的现象。它的临床应用具有很大的前景，值得进一步进行对照研究。
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