Hubei University of Chinese Medicine, Wuhan, China.
Department of Acupuncture, Hubei Provincial Hospital of Chinese Medicine, Wuhan, China.
Medicine (Baltimore). 2022 Feb 18;101(7):e28893. doi: 10.1097/MD.0000000000028893.
Stress urinary incontinence (SUI) is one of the common diseases in female urinary system diseases, and the incidence is increasing year by year. Moxibustion therapy, as a kind of acupuncture therapy, has been widely used in the clinical treatment of SUI, but its therapeutic effect and safety have not been scientifically and systematically evaluated. Therefore, the protocol of this systematic review we propose this time is to scientifically evaluate the effectiveness and safety of moxibustion in the treatment of female stress urinary incontinence (FSUI).
The following 8 electronic databases will be searched from establishment to December 2021: PubMed, Web of Science, Cochrane Library, Embase, China National Knowledge Infrastructure, VIP Database, Wanfang Database, China Biology Medicine disc. All randomized controlled trials of moxibustion in the treatment of FSUI will be searched in the above electronic databases. Two reviewers will independently complete research selection, data extraction, and research quality evaluation. After screening the studies, the quality of the included studies will be evaluated according to the quality standards specified in the Cochrane Handbook for Systematic Reviews of Interventions (version 5.1.0). The primary outcome of included studies is the change from baseline in urine leakage measured by the 1-hour pad test. Secondary outcomes include: the short-form of the International Consultation on Incontinence Questionnaire, the mean 72-hour urinary incontinence episode frequency, self-assessment of the patient's treatment effect, severity of urinary incontinence, and adverse events. Two reviewers will independently conduct study selection, data extraction, risk of bias assessment, and study quality assessment. And the STATA 14.0 software will be implemented for data synthesis and meta-analysis.
The result of this meta-analysis will be submitted to peer-reviewed journals for publication, and a comprehensive review of current evidence will be conducted.
The conclusion of this systematic review will provide evidence for judging whether moxibustion is a safer and more effective intervention for female stress urinary incontinence.
The protocol has been registered on INPLASY2021120052.
压力性尿失禁（SUI）是女性泌尿系统疾病中的常见疾病之一，其发病率呈逐年上升趋势。艾灸疗法作为一种针刺疗法，已广泛应用于 SUI 的临床治疗，但疗效和安全性尚未得到科学系统的评价。因此，本次系统评价方案旨在科学评价艾灸治疗女性压力性尿失禁（FSUI）的有效性和安全性。
从建立到 2021 年 12 月，将在以下 8 个电子数据库中搜索：PubMed、Web of Science、Cochrane Library、Embase、中国国家知识基础设施、VIP 数据库、万方数据库、中国生物医学文献数据库。将在上述电子数据库中搜索艾灸治疗 FSUI 的所有随机对照试验。两名评审员将独立完成研究选择、数据提取和研究质量评估。筛选研究后，将根据《Cochrane 干预系统评价手册》（第 5.1.0 版）规定的质量标准评估纳入研究的质量。纳入研究的主要结局是通过 1 小时垫试验测量的尿液渗漏量从基线的变化。次要结局包括：国际尿失禁咨询委员会简短问卷、平均 72 小时尿失禁发作频率、患者治疗效果自评、尿失禁严重程度和不良事件。两名评审员将独立进行研究选择、数据提取、偏倚风险评估和研究质量评估。并将使用 STATA 14.0 软件进行数据综合和荟萃分析。
该荟萃分析的结果将提交给同行评议期刊发表，并对当前证据进行综合审查。
本系统评价的结论将为判断艾灸是否是一种更安全、更有效的女性压力性尿失禁干预措施提供依据。
该方案已在 INPLASY2021120052 上注册。
