Department of Neurosurgery, The First People's Hospital of Hefei, 230061 Hefei, Anhui, China.
J Integr Neurosci. 2022 Mar 24;21(2):72. doi: 10.31083/j.jin2102072.
Traumatic brain injury (TBI), also known as head injury or brain injury, refers to the head injury caused by mechanical impact. It is necessary to develop effective new therapies for TBI injury. Gastrodin (GAS) is the main bioactive ingredient from the rhizome of and has significant therapeutic effect on nervous system diseases. However, the protective effects of GAS on brain tissue and related regulatory mechanism in traumatic brain injury remain elusive. Herein, we explored the role of GAS in traumatic brain injury and its related mechanism. We found Gastrodin reduced brain tissue injury and improved functional recovery of injury nerve in TBI rats, and alleviated inflammation. Gastrodin decreased the level of pyroptosis in brain tissue of TBI rats. Further, we found GAS suppressed NLRP3 inflammasome signaling pathway, and therefore suppressed pyroptosis and exerted neuroprotective effect. GAS could serve as a promising drug for TBI treatment.
颅脑损伤（TBI），又称头部损伤或脑损伤，是指由机械冲击引起的头部损伤。因此有必要开发治疗 TBI 损伤的有效新疗法。天麻素（GAS）是天麻根茎中的主要生物活性成分，对神经系统疾病具有显著的治疗作用。然而，GAS 对颅脑损伤脑组织的保护作用及其相关调节机制仍不清楚。本研究旨在探讨天麻素在颅脑损伤中的作用及其相关机制。研究发现天麻素可减轻 TBI 大鼠脑组织损伤，促进损伤神经功能恢复，减轻炎症反应。天麻素降低 TBI 大鼠脑组织中细胞焦亡的水平。进一步研究发现，天麻素抑制 NLRP3 炎性小体信号通路，从而抑制细胞焦亡，发挥神经保护作用。天麻素可作为治疗 TBI 的一种有前途的药物。
