Zheng Xue, Li Jing, Zhu Zhao-Qiong
Department of Anesthesiology Zunyi Matermal And Child Health Care Hospital Zunyi Guizhou China.
Department of Cardiothoracic Surgery University Medical Center Regensburg Regensburg Germany.
Ibrain. 2023 Jul 13;11(1):74-83. doi: 10.1002/ibra.12118. eCollection 2025 Spring.
Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti-inflammatory, antioxidant, antiapoptosis, and other aspects. As the global aging process continues to intensify, diseases of the central nervous system, cardiovascular system, and immune system have brought serious economic and mental burdens to families and have become a major challenge for global public health resources. Many studies have proved that gastrodin may be a potential drug for neurological diseases and ischemic injury but its mechanism of action is still unclear. [Correction added on 19 February 2025, after first online publication: In the preceding sentence, "the treatment of various systemic diseases" has been corrected to "neurological diseases and ischemic injury" in this version.]. In this study, the pharmacological action of gastrodin and the possible mechanism of regulating ferroptosis and pyroptosis were reviewed to provide a new treatment and research direction for clinicians and researchers.
天麻素作为天麻的有效单体，在抗炎、抗氧化、抗凋亡等方面发挥着重要作用。随着全球老龄化进程不断加剧，中枢神经系统、心血管系统和免疫系统疾病给家庭带来了沉重的经济和精神负担，已成为全球公共卫生资源面临的重大挑战。许多研究证明，天麻素可能是一种治疗神经疾病和缺血性损伤的潜在药物，但其作用机制仍不清楚。[2025年2月19日首次在线发表后添加的更正：在前面的句子中，此版本已将“各种全身性疾病的治疗”更正为“神经疾病和缺血性损伤”。]在本研究中，对天麻素的药理作用以及调节铁死亡和焦亡的可能机制进行了综述，为临床医生和研究人员提供了新的治疗和研究方向。
