循环血中大内皮素-1与非钙化或混合性冠状动脉粥样硬化斑块之间的关联。
Association between circulating big endothelin-1 and noncalcified or mixed coronary atherosclerotic plaques.
作者信息
Wang Fang, Li Tiewei, Cong Xiangfeng, Hou Zhihui, Lu Bin, Zhou Zhou, Chen Xi
机构信息
State Key Laboratory of Cardiovascular Disease, Center of Laboratory Medicine, Fuwai Hospital.
State Key Laboratory of Cardiovascular Disease, Department of Radiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
出版信息
Coron Artery Dis. 2019 Sep;30(6):461-466. doi: 10.1097/MCA.0000000000000752.
BACKGROUND
Noncalcified plaques (NCPs) and mixed plaques (MPs) are considered as the high-risk coronary plaques. Endothelin-1 (ET-1) is a vasoactive peptide and shows a high expression in vulnerable plaque. The aim of this study is to investigate the relationship between the bigET-1, the precursor of ET-1, and NCPs/MPs in a Chinese population.
METHODS AND RESULTS
A total of 513 patients with chest pain and suspected coronary artery disease were collected and divided into three groups with no plaques, calcified plaques, or NCPs/MPs according to the characteristics of all the plaques. It demonstrated that NCPs/MPs were associated with elevated bigET-1 (P < 0.001). Moreover, the proportion of NCPs/MPs was significantly increased from 43.3% in bigET-1 tertile 1 to 61.0% in tertile 3 group (P = 0.001). Multiple logistic regression analysis further showed that bigET-1 was an independent predictor for the presence of NCPs/MPs (odds ratio = 1.858; 95% confidence interval: 1.017-3.394; P = 0.044).
CONCLUSION
The bigET-1 could be an independent predictor for the presence of NCPs/MPs.
背景
非钙化斑块（NCPs）和混合斑块（MPs）被认为是高危冠状动脉斑块。内皮素-1（ET-1）是一种血管活性肽，在易损斑块中高表达。本研究旨在探讨ET-1的前体bigET-1与中国人群中NCPs/MPs之间的关系。
方法与结果
共收集513例胸痛且疑似冠心病患者，根据所有斑块的特征将其分为无斑块、钙化斑块或NCPs/MPs三组。结果显示，NCPs/MPs与bigET-1升高相关（P<0.001）。此外，NCPs/MPs的比例从bigET-1三分位数1组的43.3%显著增加至三分位数3组的61.0%（P = 0.001）。多因素logistic回归分析进一步表明，bigET-1是NCPs/MPs存在的独立预测因子（比值比=1.858；95%置信区间：1.017 - 3.394；P = 0.044）。
结论
bigET-1可能是NCPs/MPs存在的独立预测因子。
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