将光学化学工具和技术转移到短波红外区域，以扩展到小鼠。
Extending optical chemical tools and technologies to mice by shifting to the shortwave infrared region.
机构信息
Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California, 90095, United States.
Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California, 90095, United States.
出版信息
Curr Opin Chem Biol. 2022 Jun;68:102131. doi: 10.1016/j.cbpa.2022.102131. Epub 2022 Mar 30.
Abstract
Fluorescence imaging is an indispensable method for studying biological processes non-invasively in cells and transparent organisms. Extension into the shortwave infrared (SWIR, 1000-2000 nm) region of the electromagnetic spectrum has allowed for imaging in mammals with unprecedented depth and resolution for optical imaging. In this review, we summarize recent advances in imaging technologies, dye scaffold modifications, and incorporation of these dyes into probes for SWIR imaging in mice. Finally, we offer an outlook on the future of SWIR detection in the field of chemical biology.
摘要
荧光成像是研究细胞和透明生物体内生物过程的一种不可或缺的非侵入性方法。将电磁光谱扩展到短波红外（SWIR，1000-2000nm）区域，使得光学成象能够以前所未有的深度和分辨率对哺乳动物进行成像。在这篇综述中，我们总结了成像技术、染料支架修饰以及将这些染料整合到用于小鼠 SWIR 成像的探针中的最新进展。最后，我们对化学生物学领域中 SWIR 检测的未来进行了展望。
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