Marshall R J, Sweny P
Histopathology. 1986 Sep;10(9):953-62. doi: 10.1111/j.1365-2559.1986.tb02593.x.
We report three cases of haemolytic-uraemic syndrome following bone marrow transplantation in young males. None of them was treated with cyclosporin A. All died in renal failure. Renal histology showed the typical appearances of haemolytic-uraemic syndrome. Immunoperoxidase examination of renal biopsies showed IgM and complement in blood vessels and glomeruli of all three cases. Cytomegalovirus infection was present in two cases and probable in the third. Two cases had been infected with herpes zoster. All had episodes of graft-versus-host disease. Possible pathogenetic mechanisms are discussed.
我们报告了3例年轻男性骨髓移植后发生溶血性尿毒症综合征的病例。他们均未接受环孢素A治疗。所有患者均死于肾衰竭。肾脏组织学检查显示出溶血性尿毒症综合征的典型表现。对肾活检组织进行免疫过氧化物酶检查发现，所有3例患者的血管和肾小球中均有IgM和补体。2例患者存在巨细胞病毒感染，第3例可能感染。2例患者曾感染带状疱疹。所有患者均发生过移植物抗宿主病。文中讨论了可能的发病机制。
